斑马鱼作为发育神经毒性测试的潜在模型：小型综述。
Zebrafish as potential model for developmental neurotoxicity testing: a mini review.
机构信息
TNO, Research group Quality and Safety, Zeist, The Netherlands.
出版信息
Neurotoxicol Teratol. 2012 Nov-Dec;34(6):545-53. doi: 10.1016/j.ntt.2012.08.006. Epub 2012 Sep 3.
PMID:22971930
Abstract
The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use.
摘要
斑马鱼是一种强大的毒性模型；生化分析可以与个体的结构和功能水平的观察相结合。这篇迷你综述总结了斑马鱼作为发育神经毒性筛选模型的效力，以及其研究毒物作用机制的可能性。斑马鱼在毒性研究中的应用最终可以减少或改进动物使用。
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