Fisher E R, Palekar A S
Am J Clin Pathol. 1979 Dec;72(6):909-16. doi: 10.1093/ajcp/72.6.909.
Three neoplasms that had histologic features reminiscent of carcinoid tumors of other sites were encountered in a review of 3,300 examples of invasive mammary cancer in women (.09%). One of these showed cytoplasmic argyrophilia. This, as well as the two putative carcinoids, lacked argentaffinity. Attention is directed to the occurence of variable numbers of argyrophilic cells in eight of 19 so-called mucinous cancers of the breast studied. Further, neurosecretory-type granules were observed in cells of all four mucinous cancers suitably prepared for electron microscopic examination. The possible reasons for the lack of universal argyrophilic reactions in these lesions is discussed. It is concluded that there may be two types of mammary carcinoid tumors, the solid and mucinous varieties. No patient who had the latter type had experienced treatment failure after five years of observation. Various numbers of ductal epithelial cells in four of 45 examples of banal fibrocystic disease showed cytoplasmic argyrophilia, and neurosecretory-type granules were found in two of eight examples suitably prepared for electron microscopic examination. Whether this demonstration establishes the existence of precursor elements for the development of the carcinoid tumors is at present uncertain.
在对3300例女性浸润性乳腺癌病例（占0.09%）进行回顾时，发现了三种具有组织学特征、让人联想到其他部位类癌肿瘤的肿瘤。其中之一显示出细胞质嗜银性。这个肿瘤以及另外两个疑似类癌，缺乏亲银性。研究了19例所谓的乳腺黏液癌，其中8例出现了数量不等的嗜银细胞。此外，在所有4例经适当处理用于电子显微镜检查的黏液癌的细胞中，均观察到神经分泌型颗粒。讨论了这些病变中缺乏普遍嗜银反应的可能原因。得出的结论是，乳腺类癌肿瘤可能有两种类型，即实性和黏液性变种。患有后一种类型的患者在五年观察期后均未出现治疗失败。在45例普通纤维囊性疾病的病例中，有4例的不同数量导管上皮细胞显示出细胞质嗜银性，在8例经适当处理用于电子显微镜检查的病例中，有2例发现了神经分泌型颗粒。目前尚不确定这一发现是否能证实类癌肿瘤发展的前体元素的存在。
