Elemental Bio-imaging Facility, University of Technology, PO Box 123, Broadway, Sydney, NSW, 2007, Australia.
J Neural Transm (Vienna). 2012 Dec;119(12):1515-21. doi: 10.1007/s00702-012-0898-4. Epub 2012 Sep 13.
Redox-active iron is considered to be an important factor in the pathology and progression of several neurodegenerative disorders, including Parkinson's disease. The various roles of iron in normal physiology and its prevalence in the wider environment present numerous challenges to both accurate measurement and interpretation of brain iron levels. This review will discuss considerations for the analysis of iron in post-mortem samples, including how contamination, sample preparation and methods of analysis may influence results. In addition, several important factors influencing interpretation of iron levels will be considered.
氧化还原活性铁被认为是几种神经退行性疾病（包括帕金森病）的病理和进展的重要因素。铁在正常生理中的各种作用及其在更广泛环境中的普遍性给大脑铁水平的准确测量和解释带来了诸多挑战。本文将讨论死后样本中铁分析的注意事项，包括污染、样品制备和分析方法如何影响结果。此外，还将考虑影响铁水平解释的几个重要因素。
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