Medical Journal of Australia, Sydney, Australia.
Atomic Medicine Initiative, University of Technology, Sydney, Australia.
J Neural Transm (Vienna). 2022 Jun;129(5-6):505-520. doi: 10.1007/s00702-022-02505-5. Epub 2022 May 9.
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely why, how, and when iron is implicated in neuronal death remains the subject of investigation. In this article, we review the history of iron in movement disorders, from the first observations in the early twentieth century to recent efforts that view extrapyramidal iron as a novel therapeutic target and diagnostic indicator.
铁元素在帕金森病和相关疾病中的作用由来已久。这种必需的微量元素对大脑正常功能至关重要，但一个世纪以来，大脑中铁元素的异常积累与锥体外系疾病有关。确切的原因、方式和时间，以及铁元素如何导致神经元死亡，仍然是研究的主题。在本文中，我们回顾了铁元素在运动障碍中的历史，从 20 世纪初的最初观察到最近的研究进展，这些研究将锥体外系铁元素视为一种新的治疗靶点和诊断指标。
