Laboratory of Developmental Biology, Instituto de Investigaciones Biotecnológicas- Instituto Tecnológico de Chascomús, Chascomús, Argentina.
Dev Dyn. 2012 Dec;241(12):1849-56. doi: 10.1002/dvdy.23868. Epub 2012 Sep 25.
The neural crest (NC) is a multipotent, migratory cell population that arises from the dorsal neural fold of vertebrate embryos. NC cells migrate extensively and differentiate into a variety of tissues, including melanocytes, bone, and cartilage of the craniofacial skeleton, peripheral and enteric neurons, glia, and smooth muscle and endocrine cells. For several years, the gene regulatory network that orchestrates NC cells development has been extensively studied. However, we have recently begun to understand that epigenetic and posttranscriptional regulation, such as miRNAs, plays important roles in NC development. In this review, we focused on some of the most recent findings on chromatin-dependent mechanisms and miRNAs regulation during vertebrate NC cells development.
神经嵴（NC）是一种多能、迁移的细胞群体，起源于脊椎动物胚胎的背侧神经褶。NC 细胞广泛迁移并分化为多种组织，包括黑色素细胞、颅面骨骼的骨和软骨、周围和肠神经元、神经胶质、平滑肌和内分泌细胞。几年来，调控 NC 细胞发育的基因调控网络已被广泛研究。然而，我们最近开始了解到，表观遗传和转录后调控，如 miRNA，在 NC 发育中起着重要作用。在这篇综述中，我们重点介绍了一些关于染色质依赖机制和 miRNA 在脊椎动物 NC 细胞发育过程中的调控的最新发现。
