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Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: preliminary safety results from the CHHiP randomised controlled trial.常规分割与低分割高剂量强度调制放疗治疗前列腺癌:来自 CHHiP 随机对照试验的初步安全性结果。
Lancet Oncol. 2012 Jan;13(1):43-54. doi: 10.1016/S1470-2045(11)70293-5. Epub 2011 Dec 12.
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The physical basis and future of radiation therapy.放射治疗的物理基础与未来。
Br J Radiol. 2011 Jun;84(1002):485-98. doi: 10.1259/bjr/86221320.
3
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial.腮腺保留调强放疗与常规放疗治疗头颈部肿瘤(PARSPORT):一项 3 期多中心随机对照试验。
Lancet Oncol. 2011 Feb;12(2):127-36. doi: 10.1016/S1470-2045(10)70290-4. Epub 2011 Jan 12.
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Hypofractionated whole-breast radiotherapy for women with early breast cancer: myths and realities.早期乳腺癌女性的大分割全乳放疗:误区与真相
Int J Radiat Oncol Biol Phys. 2011 Jan 1;79(1):1-9. doi: 10.1016/j.ijrobp.2010.08.035. Epub 2010 Oct 13.
5
Survey of the availability and use of advanced radiotherapy technology in the UK.英国先进放疗技术的供应和使用情况调查。
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6
Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02.放疗方案依从性和质量对晚期头颈部癌症治疗的关键影响:来自 TROG 02.02 的结果。
J Clin Oncol. 2010 Jun 20;28(18):2996-3001. doi: 10.1200/JCO.2009.27.4498. Epub 2010 May 17.
7
Radiotherapy research priorities for the UK.英国的放射治疗研究重点。
Clin Oncol (R Coll Radiol). 2010 Oct;22(8):707-9. doi: 10.1016/j.clon.2010.03.006. Epub 2010 Apr 2.
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A new opportunity for radiotherapy research in the UK.
Clin Oncol (R Coll Radiol). 2009 Apr;21(3):157-8. doi: 10.1016/j.clon.2008.12.007. Epub 2009 Jan 24.
9
The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial.英国早期乳腺癌放疗超分割标准化(START)试验A:一项随机试验。
Lancet Oncol. 2008 Apr;9(4):331-41. doi: 10.1016/S1470-2045(08)70077-9. Epub 2008 Mar 19.
10
The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial.英国早期乳腺癌放疗超分割治疗标准化(START)试验B:一项随机试验
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英国放射物理学研究:挑战与解决方案。

Radiotherapy physics research in the UK: challenges and proposed solutions.

机构信息

Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.

出版信息

Br J Radiol. 2012 Oct;85(1018):1354-62. doi: 10.1259/bjr/61530686.

DOI:10.1259/bjr/61530686
PMID:22972972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3474027/
Abstract

In 2011, the Clinical and Translational Radiotherapy Research Working Group (CTRad) of the National Cancer Research Institute brought together UK radiotherapy physics leaders for a think tank meeting. Following a format that CTRad had previously and successfully used with clinical oncologists, 23 departments were asked to complete a pre-meeting evaluation of their radiotherapy physics research infrastructure and the strengths, weaknesses, opportunities and threats within their own centre. These departments were brought together with the CTRad Executive Group and research funders to discuss the current state of radiotherapy physics research, perceived barriers and possible solutions. In this Commentary, we summarise the submitted materials, presentations and discussions from the meeting and propose an action plan. It is clear that there are challenges in both funding and staffing of radiotherapy physics research. Programme and project funding streams sometimes struggle to cater for physics-led work, and increased representation on research funding bodies would be valuable. Career paths for academic radiotherapy physicists need to be examined and an academic training route identified within Modernising Scientific Careers; the introduction of formal job plans may allow greater protection of research time, and should be considered. Improved access to research facilities, including research linear accelerators, would enhance research activity and pass on developments to patients more quickly; research infrastructure could be benchmarked against centres in the UK and abroad. UK National Health Service departments wishing to undertake radiotherapy research, with its attendant added value for patients, need to develop a strategy with their partner higher education institution, and collaboration between departments may provide enhanced opportunities for funded research.

摘要

2011 年,英国国家癌症研究所的临床与转化放射治疗研究工作组(CTRad)召集了英国放射治疗物理学领域的领导者举行了一次智库会议。该会议采用了 CTRad 先前与临床肿瘤学家成功使用的格式,要求 23 个部门在会议前评估其放射治疗物理研究基础设施,以及各自中心的优势、劣势、机会和威胁。这些部门与 CTRad 执行小组和研究资助者一起讨论了放射治疗物理研究的现状、感知到的障碍和可能的解决方案。在这篇评论中,我们总结了会议提交的材料、演示文稿和讨论,并提出了行动计划。显然,放射治疗物理研究的资金和人员配置都存在挑战。项目和计划资金流有时难以满足物理主导工作的需求,增加在研究资助机构中的代表性将是有价值的。学术放射治疗物理学家的职业道路需要进行审查,并在现代科学职业中确定学术培训途径;引入正式的工作规划可能会允许更多地保护研究时间,应加以考虑。更好地利用研究设施,包括研究线性加速器,将增强研究活动,并更快地将进展传递给患者;研究基础设施可以与英国和国外的中心进行基准测试。希望开展放射治疗研究的英国国民保健制度部门,需要与其合作的高等教育机构制定一项战略,部门间的合作可能为有资金支持的研究提供更多机会。