McDonald M B, Frantz J M, Klyce S D, Beuerman R W, Varnell R, Munnerlyn C R, Clapham T N, Salmeron B, Kaufman H E
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
Arch Ophthalmol. 1990 Jun;108(6):799-808. doi: 10.1001/archopht.1990.01070080041033.
Prior to undertaking a study in sighted human eyes, we performed photorefractive keratectomy with the 193-nm excimer laser for the correction of myopia in nine legally blind eyes to evaluate safety, efficacy, predictability, and stability. In most cases, reepithelialization was complete by 5 days after surgery; no recurrent erosions were seen. By the end of the 6-month study, all of the corneas had a 0 or 1+ clarity score, on a scale of 0 (clear) to 5+ (opaque). Keratometry and pachometry demonstrated stable flattening of the corneas. One month after surgery, changes in refraction evaluated by retinoscopy showed fair predictability, with no significant increase in refractive or keratometric astigmatism, followed by some regression of effect by the end of the study, possibly caused by anatomical remodeling. The amount of regression appeared to be directly related to the amount of correction intended, suggesting that this effect would not be clinically important in the treatment of mild to moderate myopia.
在对有视力的人眼进行研究之前，我们用193纳米准分子激光对9只法定盲人眼进行了屈光性角膜切削术以矫正近视，从而评估安全性、有效性、可预测性和稳定性。在大多数情况下，术后5天角膜上皮化完成；未见复发性糜烂。到6个月研究结束时，所有角膜的清晰度评分为0或1+，评分范围为0（透明）至5+（不透明）。角膜曲率测量和角膜厚度测量显示角膜稳定变平。术后1个月，通过检影验光评估的屈光变化显示出较好的可预测性，屈光性或角膜散光无明显增加，随后到研究结束时效果出现一定程度的消退，这可能是由解剖结构重塑引起的。消退量似乎与预期矫正量直接相关，表明这种效应在治疗轻度至中度近视时在临床上并不重要。
