Vafa Mohammadreza, Mohammadi Farhad, Shidfar Farzad, Sormaghi Mohammadhossein Salehi, Heidari Iraj, Golestan Banafshe, Amiri Fatemehsadat
Department of Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2012 Aug;3(8):531-6.
Type 2 diabetes is the most common metabolic disorder worldwide. Traditional herbs and spices can be used to control blood glucose concentrations. The objective of this study was to evaluate the effects of the daily intake of three grams cinnamon over eight weeks on glycemic status, lipid profiles and body composition in type 2 diabetic patients.
A double blind, randomized, placebo controlled clinical trial was conducted on 44 patients with type 2 diabetes. Participants were randomly assigned to take either a three g/day cinnamon supplement (n=22) or a placebo (n=22) for eight weeks. Weight, height, body fat mass and systolic and diastolic blood pressure were measured at baseline and after intervention. The fasting blood glucose, insulin, HbA1c, total cholesterol, LDL C, HDL C, Apo lipoprotein A I and B were measured at baseline and endpoint.
From 44 subjects participated in this study 37 completed the study. There were no significant differences in baseline characteristics, dietary intake and physical activity between groups. In the treatment group, the levels of fasting blood glucose, HbA1c, triglyceride, weight, BMI and body fat mass decreased significantly compared to baseline, but not in placebo group. No significant differences were observed in glycemic status indicators, lipid profile and anthropometric indicators between the groups at the end of intervention.
These data suggest that cinnamon may have a moderate effect in improving glycemic status indicators.
2型糖尿病是全球最常见的代谢紊乱疾病。传统草药和香料可用于控制血糖浓度。本研究的目的是评估2型糖尿病患者连续八周每日摄入3克肉桂对血糖状态、血脂谱和身体成分的影响。
对44例2型糖尿病患者进行了一项双盲、随机、安慰剂对照临床试验。参与者被随机分配服用3克/天的肉桂补充剂(n = 22)或安慰剂(n = 22),为期八周。在基线和干预后测量体重、身高、体脂肪量以及收缩压和舒张压。在基线和终点测量空腹血糖、胰岛素、糖化血红蛋白、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A I和B。
参与本研究的44名受试者中有37名完成了研究。两组之间在基线特征、饮食摄入和身体活动方面没有显著差异。在治疗组中,与基线相比,空腹血糖、糖化血红蛋白、甘油三酯、体重、体重指数和体脂肪量水平显著下降,但安慰剂组未出现这种情况。干预结束时,两组之间在血糖状态指标、血脂谱和人体测量指标方面未观察到显著差异。
这些数据表明肉桂可能在改善血糖状态指标方面有适度作用。