Gougelet Angélique, Colnot Sabine
INSERM, U1016, Institut Cochin, 75014 Paris, France.
Int J Hepatol. 2012;2012:816125. doi: 10.1155/2012/816125. Epub 2012 Sep 3.
Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver cancers and a physiological signalling identified as the "zonation-keeper" of the quiescent liver lobule. This duality has encouraged to explore the role of canonical Wnt in liver regeneration and liver-cell proliferation mainly using murine genetic models of β-catenin overactivation or inactivation. These studies definitely integrate Wnt signalling within the hepatic network driving regeneration and proliferation. We will review here the current knowledge concerning the mitogenic effect of Wnt, to switch on its specific role in the liver, which is quiescent but with a great capacity to regenerate. The duality of β-catenin signalling, associated both with liver quiescence and liver-cell proliferation, will be brought forward.
由其效应因子β-连环蛋白调控的经典Wnt信号通路，长期以来一直被认为在发育、组织稳态和癌症中发挥着重要作用。在肝脏中，它既被揭示为参与一部分肝癌的致癌途径，也被确定为静止肝小叶的“分区维持者”这一生理信号。这种双重性促使人们主要利用β-连环蛋白过度激活或失活的小鼠遗传模型来探索经典Wnt在肝脏再生和肝细胞增殖中的作用。这些研究明确将Wnt信号整合到驱动再生和增殖的肝脏网络中。在此，我们将回顾目前关于Wnt促有丝分裂作用的知识，以明确其在静止但具有强大再生能力的肝脏中的特定作用。β-连环蛋白信号与肝脏静止和肝细胞增殖相关的双重性将被提出。
