Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Headache. 2012 Nov-Dec;52(10):1499-505. doi: 10.1111/j.1526-4610.2012.02250.x. Epub 2012 Sep 13.
High prevalence of headache has been associated with high latitude, thus suggesting a relation with vitamin D. However, there are so far no reports on the association between serum 25-hydroxyvitamin D (25[OH]D) and headache.
To investigate the association between headache and serum 25(OH)D in a general population.
Cross-sectional study based on questionnaires from 11,614 persons who participated in the sixth survey of the Tromsø Study (Tromsø 6) carried out in 2007-2008. The data were stratified according to smoking status and analyzed with regard to migraine and non-migraine headache. Adjustments were done for age, body mass index (BMI), gender, season, chronic diseases, education, physical exercise, and alcohol consumption.
Headache of non-migraine type was associated with low levels of serum 25(OH)D with an odds ratio (OR) of 1.20 (1.04-1.39) in the lowest quartile as compared to the highest serum 25(OH)D quartile. No significant association was found between migraine and serum 25(OH)D.
Non-migraine headache was associated with low levels of serum 25(OH)D. Although adjustment were done for possible confounders, this finding may still reflect lifestyle rather than causality, and further studies are needed to investigate this. No association was found between serum 25(OH)D and migraine.
高纬度地区头痛的发病率较高，因此提示维生素 D 可能与之相关。然而，目前尚无血清 25-羟维生素 D（25[OH]D）与头痛之间关联的报告。
在一般人群中调查头痛与血清 25（OH）D 之间的关系。
基于 2007-2008 年进行的特罗姆瑟研究第六次调查（特罗姆瑟 6 号）中 11614 名参与者的问卷调查进行了横断面研究。根据吸烟状况对数据进行分层，并分析偏头痛和非偏头痛性头痛。对年龄、体重指数（BMI）、性别、季节、慢性疾病、教育、体育锻炼和饮酒进行了调整。
与血清 25（OH）D 水平最高四分位相比，血清 25（OH）D 水平最低四分位的非偏头痛性头痛的比值比（OR）为 1.20（1.04-1.39）。未发现偏头痛与血清 25（OH）D 之间存在显著相关性。
非偏头痛性头痛与血清 25（OH）D 水平较低有关。尽管对可能的混杂因素进行了调整，但这一发现可能仍然反映了生活方式而不是因果关系，需要进一步研究来探讨这一点。未发现血清 25（OH）D 与偏头痛之间存在关联。
