Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Neurobiology, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Sci Rep. 2017 Jan 3;7:39697. doi: 10.1038/srep39697.
Vitamin D has been suggested to have a role in various neurovascular diseases, but the data regarding headache is inconclusive. Our aim was to investigate the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker for vitamin D status, and risk of frequent headache. The study population consisted of 2601 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) from eastern Finland, aged 42-60 years in 1984-1989. The cross-sectional associations with prevalence of self-reported frequent headache (defined as weekly or daily headaches) were estimated with multivariable-adjusted odds ratios. The average serum 25(OH) concentration was 43.4 nmol/L (SD 18.9, min-max 7.8-136.1 nmol/L). A total of 250 men (9.6%) reported frequent headache. The average serum 25(OH)D concentration among those with frequent headache was 38.3 nmol/L (SD 18.8) and 43.9 nmol/L (SD 18.9) among those without frequent headache, after adjustment for age and year and month of blood draw (P for difference <0.001). After multivariable adjustments, those in the lowest vs. the highest serum 25(OH)D quartile had 113% (95% CI 42, 218%; P for trend <0.001) higher odds for frequent headache. In conclusion, low serum 25(OH)D concentration was associated with markedly higher risk of frequent headache in men.
维生素 D 被认为在各种神经血管疾病中发挥作用，但关于头痛的数据尚无定论。我们的目的是研究血清 25-羟维生素 D [25(OH)D]（维生素 D 状态的标志物）与频发头痛风险之间的关联。该研究人群包括来自芬兰东部的基于人群的库奥皮奥缺血性心脏病风险因素研究（KIHD）的 2601 名男性，年龄在 1984-1989 年为 42-60 岁。使用多变量调整后的优势比来估计与自我报告频发头痛（定义为每周或每天头痛）的患病率的横断面关联。平均血清 25(OH)浓度为 43.4 nmol/L（SD 18.9，最小值-最大值 7.8-136.1 nmol/L）。共有 250 名男性（9.6%）报告频发头痛。频发头痛者的平均血清 25(OH)D 浓度为 38.3 nmol/L（SD 18.8），无频发头痛者的平均血清 25(OH)D 浓度为 43.9 nmol/L（SD 18.9），调整年龄、采血年份和月份后（差异 P 值 <0.001）。多变量调整后，血清 25(OH)D 最低四分位数与最高四分位数相比，频发头痛的优势比为 113%（95%CI 42，218%；趋势 P 值 <0.001）。总之，血清 25(OH)D 浓度低与男性频发头痛的风险显著增加相关。
