Hao Shunfa, Qian Renyi, Chen Yiru, Liu Jingfang, Xu Xiaoyan, Guan Yunxiang
Department of Encephalopathy, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
The First Clinical Medical School, Henan University of Traditional Chinese Medicine, Zhengzhou, China.
PLoS One. 2025 Jan 3;20(1):e0313082. doi: 10.1371/journal.pone.0313082. eCollection 2025.
Vitamin D is thought to play a role in the development of migraine, but the nature of the relationship is still not fully understood. Although some studies have shown an association between vitamin D deficiency and migraine, other studies have had inconsistent or inconclusive results. Therefore, further research is needed to better understand the relationship between vitamin D and migraine headaches.
We selected 9142 participants from the 2001-2004 National Health and Nutrition Examination Survey (NHANES). In our study, the term "serum vitamin D" refers to the concentration of 25OHD2 + 25OHD3 (nmol/L) in the blood. Migraine was assessed based on self-reports in the miscellaneous pain section of the NHANES questionnaire. Associations between vitamin D and the risk of migraine were examined using multiple logistic regression, smoothed curve fitting, and stratified analyses.
In our study, 20.53% of the participants suffered from migraine. The prevalence of migraine was higher in those with lower serum vitamin D levels. Participants in the highest quartile of serum vitamin D levels were found to have a 16% lower prevalence than those in the lowest quartile in the fully adjusted model (OR = 0.84, 95% CI 0.71-0.99). This result was supported by stratified analysis and smoothed curve fitting.
Our study showed a significant negative correlation between serum vitamin D levels and the prevalence of migraine in American adults.
维生素D被认为在偏头痛的发病过程中起作用，但其关系的本质仍未完全明确。尽管一些研究表明维生素D缺乏与偏头痛之间存在关联，但其他研究结果并不一致或尚无定论。因此，需要进一步研究以更好地理解维生素D与偏头痛之间的关系。
我们从2001 - 2004年美国国家健康与营养检查调查（NHANES）中选取了9142名参与者。在我们的研究中，“血清维生素D”一词指血液中25OHD2 + 25OHD3的浓度（nmol/L）。偏头痛是根据NHANES问卷中杂项疼痛部分的自我报告进行评估的。使用多重逻辑回归、平滑曲线拟合和分层分析来检验维生素D与偏头痛风险之间的关联。
在我们的研究中，20.53%的参与者患有偏头痛。血清维生素D水平较低的参与者中偏头痛的患病率较高。在完全调整模型中，血清维生素D水平处于最高四分位数的参与者的患病率比最低四分位数的参与者低16%（OR = 0.84，95%CI 0.71 - 0.99）。这一结果得到了分层分析和平滑曲线拟合的支持。
我们的研究表明，美国成年人血清维生素D水平与偏头痛患病率之间存在显著的负相关。
