Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Chem Biol Drug Des. 2012 Dec;80(6):821-7. doi: 10.1111/cbdd.12053.
Unprotected S-acylated cysteine isopeptides containing α-, β- or γ-amino acid units have been synthesized, and their conversion to native hexapeptides by S- to the N-terminus ligations involving 17-, 18- and 19-membered cyclic transition states have been demonstrated both experimentally and computationally to be more favorable than intermolecular cross-ligations.
已合成了含有α、β或γ-氨基酸单元的未保护 S-酰化半胱氨酸异肽，并通过涉及 17、18 和 19 元环过渡态的 S 到 N 末端连接实验和计算证明，将其转化为天然六肽比分子间交叉连接更有利。
