Department of Cardiology, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Cytokine. 2012 Dec;60(3):674-80. doi: 10.1016/j.cyto.2012.08.012. Epub 2012 Sep 11.
Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV complications during long-term follow-up.
EAT and SAT samples were obtained during surgery - mainly CABG (n=77) - from 137 patients (mean age 69.9 years, 31% women). Adiponectin and leptin mRNA levels were analyzed by RT-PCR. Plasma adiponectin levels were determined in a subsample of subjects (n=43). Thirty-four patients developed CV complications during 41 (SD 23) months of mean follow-up. Patients with CV events had lower EAT and SAT adiponectin levels at baseline (12.4 (3.0) vs. 15.7 (3.8) a.u., P=0.001; and 13.7 (2.6) vs. 15.7 (4.4) a.u., P=0.048, respectively). However, baseline EAT and SAT leptin levels and plasma adiponectin levels were not significantly different between patients with/without CV events during follow-up. Cox proportional hazards models adjusting for covariates in stages revealed that only baseline EAT adiponectin levels and heart failure could predict CV events.
EAT adiponectin levels are strong predictors of CV prognosis in patients with CV diseases. EAT is likely to play a major role in the development of CV complications mainly through local effects.
心外膜脂肪组织（EAT）产生广泛的脂肪因子，最近与心血管（CV）和代谢疾病的病理生理学有关。我们旨在研究 EAT 和皮下（SAT）脂联素和瘦素表达水平是否与长期随访期间的 CV 并发症有关。
在手术期间（主要是 CABG，n=77）从 137 名患者（平均年龄 69.9 岁，31%为女性）中获得 EAT 和 SAT 样本。通过 RT-PCR 分析脂联素和瘦素 mRNA 水平。在亚组受试者（n=43）中测定血浆脂联素水平。34 例患者在平均 41（SD 23）个月的随访中发生 CV 并发症。CV 事件患者的基线 EAT 和 SAT 脂联素水平较低（12.4（3.0）与 15.7（3.8）a.u.，P=0.001；和 13.7（2.6）与 15.7（4.4）a.u.，P=0.048）。然而，在随访期间，CV 事件患者的基线 EAT 和 SAT 瘦素水平和血浆脂联素水平无显著差异。在逐步调整协变量的 Cox 比例风险模型中，只有基线 EAT 脂联素水平和心力衰竭才能预测 CV 事件。
EAT 脂联素水平是 CV 疾病患者 CV 预后的强预测因子。EAT 可能主要通过局部作用在心外膜脂肪组织中发挥主要作用。
