Department of Cardiology, Hospital Clínico Universitario, Santiago de Compostela, Spain.
Cytokine. 2011 May;54(2):185-90. doi: 10.1016/j.cyto.2011.01.016. Epub 2011 Feb 16.
Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether EAT and subcutaneous adipose tissue (SAT) adiponectin mRNA levels are similar in patients with and without MS.
EAT, SAT and blood samples were collected from patients undergoing elective cardiac surgery, for revascularization (n=19) or other procedures (n=27). Plasma adiponectin was measured using ELISA. mRNA was purified and adiponectin mRNA quantified by real time RT-PCR.
Mean (SD) age was 71.6 (9.6) years. Patients who met Adult Treatment Panel III MS criteria (n=29) presented lower plasma adiponectin concentrations (11.2 (7.4) vs. 19.6 (8.4) mg/l, P=0.004), lower EAT adiponectin mRNA (12.7 (3.0) vs. 15.1 (3.7) a.u., P=0.029) and similar SAT adiponectin mRNA levels (13.7 (4.2) vs. 15.6 (5.7) a.u., P=0.25) than those without MS. After adjusting for age, sex, CAD and heart failure, the association with MS remained statistically significant for plasma adiponectin (OR 0.862 (0.762-0.974)), was of borderline significance for EAT adiponectin mRNA (OR 0.796 (0.630-1.005)) and not significant for SAT adiponectin mRNA (OR 0.958 (0.818-1.122)). Patients in the lower quartiles of EAT adiponectin mRNA and plasma adiponectin presented a higher mean of components of the MS.
Subjects with MS present lower EAT adiponectin mRNA levels than those without MS, whereas SAT adiponectin mRNA levels do not seem to differ between both groups. EAT might be the link between MS and its atherothrombotic cardiac complications.
脂联素是一种抗动脉粥样硬化的胰岛素增敏激素，其在代谢综合征（MS）患者中的血浆浓度较低。内脏肥胖，包括心外膜脂肪组织（EAT），与 MS 和冠心病（CAD）的发展密切相关。我们试图研究 EAT 和皮下脂肪组织（SAT）脂联素 mRNA 水平在有无 MS 的患者中是否相似。
从接受择期心脏手术的患者中采集 EAT、SAT 和血液样本，进行血运重建（n=19）或其他手术（n=27）。使用 ELISA 法测量血浆脂联素。纯化 mRNA，实时 RT-PCR 定量脂联素 mRNA。
平均（SD）年龄为 71.6（9.6）岁。符合成人治疗小组 III 型 MS 标准的患者（n=29）血浆脂联素浓度较低（11.2（7.4）vs. 19.6（8.4）mg/l，P=0.004），EAT 脂联素 mRNA 也较低（12.7（3.0）vs. 15.1（3.7）au，P=0.029），SAT 脂联素 mRNA 水平相似（13.7（4.2）vs. 15.6（5.7）au，P=0.25）。在调整年龄、性别、CAD 和心力衰竭后，MS 与血浆脂联素仍呈统计学显著相关（OR 0.862（0.762-0.974）），与 EAT 脂联素 mRNA 呈边缘显著相关（OR 0.796（0.630-1.005）），与 SAT 脂联素 mRNA 无显著相关（OR 0.958（0.818-1.122））。EAT 脂联素 mRNA 和血浆脂联素低值四分位数的患者具有更高的 MS 成分平均值。
MS 患者的 EAT 脂联素 mRNA 水平低于无 MS 患者，而 SAT 脂联素 mRNA 水平似乎在两组之间没有差异。EAT 可能是 MS 及其动脉粥样血栓性心脏并发症之间的联系。
