Unité de Recherche en Génomique Végétale, INRA-UEVE UMR1165, CNRS ERL8196, Evry, France.
Trends Plant Sci. 2013 Jan;18(1):30-40. doi: 10.1016/j.tplants.2012.08.008. Epub 2012 Sep 10.
Ca(2+) has long been recognized as a conserved second messenger and principal mediator in plant immune and stress responses. How Ca(2+) signals are sensed and relayed into diverse primary and global signaling events is still largely unknown. Comprehensive analyses of the plant-specific multigene family of Ca(2+)-dependent protein kinases (CDPKs) are unraveling the molecular, cellular and genetic mechanisms of Ca(2+) signaling. CDPKs, which exhibit overlapping and distinct expression patterns, sub-cellular localizations, substrate specificities and Ca(2+) sensitivities, play versatile roles in the activation and repression of enzymes, channels and transcription factors. Here, we review the recent advances on the multifaceted functions of CDPKs in the complex immune and stress signaling networks, including oxidative burst, stomatal movements, hormonal signaling and gene regulation.
钙离子（Ca(2+)）长期以来一直被认为是植物免疫和应激反应中保守的第二信使和主要介质。Ca(2+)信号如何被感知并传递到各种初级和全局信号事件中，在很大程度上仍然未知。对植物特异性多基因家族钙依赖蛋白激酶（CDPKs）的综合分析正在揭示 Ca(2+)信号转导的分子、细胞和遗传机制。CDPKs 表现出重叠和独特的表达模式、亚细胞定位、底物特异性和 Ca(2+)敏感性，在激活和抑制酶、通道和转录因子方面发挥着多种作用。在这里，我们综述了 CDPKs 在复杂的免疫和应激信号网络中的多方面功能的最新进展，包括氧化爆发、气孔运动、激素信号和基因调控。
