Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.
Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, 24 chemin de Borde Rouge, Auzeville, BP 42617, 31326 Castanet Tolosan, France.
Trends Plant Sci. 2017 Mar;22(3):263-272. doi: 10.1016/j.tplants.2016.11.007. Epub 2017 Jan 3.
Calcium-dependent protein kinases (CDPKs) are Ca-sensors that play pivotal roles in plant development and stress responses. They have the unique ability to directly translate intracellular Ca signals into reversible phosphorylation events of diverse substrates which can mediate interactions with 14-3-3 proteins to modulate protein functions. Recent studies have revealed roles for the coordinated action of CDPKs and 14-3-3s in regulating diverse aspects of plant biology including metabolism, development, and stress responses. We review here the underlying interaction and cross-regulation of the two signaling proteins, and we discuss how this insight has led to the emerging concept of CDPK/14-3-3 signaling modules that could contribute to response specificity.
钙依赖蛋白激酶（CDPKs）是 Ca 传感器，在植物发育和应激反应中起着关键作用。它们具有独特的能力，可将细胞内 Ca 信号直接转化为不同底物的可逆磷酸化事件，从而介导与 14-3-3 蛋白的相互作用，调节蛋白质功能。最近的研究揭示了 CDPK 和 14-3-3 协调作用在调节植物生物学的多个方面，包括代谢、发育和应激反应中的作用。在这里，我们综述了这两种信号蛋白的潜在相互作用和交叉调控，并讨论了这一见解如何导致新兴的 CDPK/14-3-3 信号模块概念的出现，该概念可能有助于响应的特异性。
