小脑作为雌激素作用的靶点。
The cerebellum as a target for estrogen action.
机构信息
Department of Neuroscience and Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, United States.
出版信息
Front Neuroendocrinol. 2012 Oct;33(4):403-11. doi: 10.1016/j.yfrne.2012.08.005. Epub 2012 Sep 5.
Abstract
This review focuses on the effects of estrogens upon the cerebellum, a brain region long ignored as a site of estrogen action. Highlighted are the diverse effects of estradiol within the cerebellum, emphasizing the importance of estradiol signaling in cerebellar development, modulation of synaptic neurotransmission in the adult, and the potential influence of estrogens on various health and disease states. We also provide new data, consistent with previous studies, in which locally synthesized estradiol modulates cerebellar glutamatergic neurotransmission, providing one underlying mechanism by which the actions of estradiol can affect this brain region.
摘要
这篇综述重点介绍了雌激素对小脑的影响，小脑是一个长期被忽视的雌激素作用部位。本文强调了雌二醇在小脑中的多种作用，强调了雌二醇信号在小脑发育、成人突触神经传递调节以及雌激素对各种健康和疾病状态的潜在影响的重要性。我们还提供了与先前研究一致的新数据，表明局部合成的雌二醇调节小脑谷氨酸能神经传递，这为雌二醇的作用如何影响这个脑区提供了一个潜在的机制。
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