Effect of forskolin on synthesis of xyloside-initiated glycosaminoglycans in embryonic chick chondrocytes.
作者信息
Hu L M, Kemp S F, Elders M J, Smith W G
机构信息
Department of Biochemistry/Molecular Biology, University of Arkansas for Medical Science, Little Rock.
出版信息
Biochim Biophys Acta. 1990 Jan 23;1051(1):112-4. doi: 10.1016/0167-4889(90)90181-c.
PMID:2297536
Abstract
The synthesis of sulfated glycosaminoglycan (GAG) chains has been studied in the presence of various concentrations of the artificial acceptor 4-methylumbelliferyl beta-D-xyloside and of forskolin. Sulfated GAG chains formed in the presence of forskolin had a smaller hydrodynamic radius than controls, as revealed by chromatography on Sepharose CL-6B. Sulfated GAGs from both control and treated cultures behaved identically when chromatographed on DEAE.
摘要
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