Department of Orthopedics, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRJ 1120, Boston, MA 02114, USA.
J Neurosci Methods. 2012 Nov 15;211(2):237-44. doi: 10.1016/j.jneumeth.2012.09.002. Epub 2012 Sep 10.
It is well recognized that micrometer and nanometer sized surface features enhance the skeletal attachment of implants within bone. However, little is known regarding the integration of implants placed outside the bone but in contact with the surface. Loosening of chronic skull anchored headposts in non-human primate based experiments can be a factor. The purpose of this study was to evaluate the effect of a simple and easily applied surface texture on bone apposition to titanium implants fixed to the periosteal surface of the skull. Implants possessed either a polished surface or a textured surface created by grit-basting followed by acid etching. The percent of bone in contact with the implant surface (bone apposition) to three polished and three textured implants was evaluated in one adult female monkey after 14 weeks. Upon harvest, implants were processed for undecalcified histology and regions of bone apposition were quantified using backscatter electron microscopy and digital image analysis. The bone apposition to textured implants was 62±20% and to polished implants was 42±21%. The application of a peak-and-pit like texture to the surface of titanium implants significantly increased bone apposition to titanium implants placed on the periosteal surface of the skull. This study demonstrates that titanium headposts can easily be modified to improve osseointegration using equipment and supplies available to most neurophysiological laboratories. In addition, implant texturing may have utility in areas including skeletal trauma and reconstruction where devices are placed in contact with the bone surface.
众所周知，微米和纳米级别的表面特征可以增强植入物在骨骼内的骨附着。然而，对于植入物放置在骨骼外部但与表面接触的情况，人们知之甚少。在非人类灵长类动物的实验中，慢性颅骨锚固头钉松动可能是一个因素。本研究的目的是评估一种简单且易于应用的表面纹理对钛植入物固定在颅骨骨膜表面时骨附着的影响。植入物具有抛光表面或通过喷砂后酸蚀形成的纹理表面。在 14 周后，在一只成年雌性猴子中评估了三种抛光植入物和三种纹理植入物的骨与植入物表面接触的百分比（骨附着）。收获后，对植入物进行不脱钙组织学处理，并使用背散射电子显微镜和数字图像分析对骨附着区域进行定量。纹理植入物的骨附着率为 62±20%，抛光植入物的骨附着率为 42±21%。在钛植入物表面应用峰谷状纹理显著增加了钛植入物在颅骨骨膜表面的骨附着。本研究表明，使用大多数神经生理学实验室都具备的设备和材料，可以很容易地对钛头钉进行修改，以提高其骨整合能力。此外，在与骨表面接触的骨骼创伤和重建等领域，植入物纹理可能具有实用性。
