Hsieh Chang-Wei, Li Po-Hsien, Lu I-Chi, Wang Teng-Hsu
Department of Medicinal Botany and Healthcare, Da-Yeh University, Dacun, Changhua, Taiwan, Republic of China.
J Oleo Sci. 2012;61(9):483-9. doi: 10.5650/jos.61.483.
Glabridin is a pharmacological active hydrophobic pyranoisoflavan isolated from licorice. It has low bioavailability and solubility and therefore is difficult to apply for industry use. We investigated the effect of combining caprylic triglyceride with glabridin (2-6%, w/w), emulsifier (3-7%, w/w), and homogenization pressure (70-130 MPa) on the droplet size of glabridin nanoemulsions using response surface methodology by a 3-factor-3-level Box-Behnken design. Oil content, emulsifier content and pressure had a significant effect on droplet size (p < 0.05). The optimal conditions for preparing glabridin nanoemulsions were predicted to be caprylic triglyceride (oil content), 3.7%; emulsifier content, 5.3%, and homogenization pressure, 129 MPa.
光甘草定是一种从甘草中分离出的具有药理活性的疏水性吡喃异黄酮。它的生物利用度和溶解度较低，因此难以应用于工业生产。我们采用三因素三水平的Box-Behnken设计，通过响应面法研究了辛酸甘油三酯与光甘草定（2-6%，w/w）、乳化剂（3-7%，w/w）以及均质压力（70-130MPa）的组合对光甘草定纳米乳液粒径的影响。油相含量、乳化剂含量和压力对粒径有显著影响（p<0.05）。制备光甘草定纳米乳液的最佳条件预计为：辛酸甘油三酯（油相含量）3.7%；乳化剂含量5.3%，均质压力129MPa。
