Patel P V, Patel A, Kumar S, Holmes J C
Kalindi Oro Care and Research Centre, Lanka, Uttar Pradesh, India.
Minerva Stomatol. 2012 Sep;61(9):381-98.
The aim of this paper was to evaluate the efficacy of ozonated olive oil as a monotherapy and an adjunct to scaling and root planing in the treatment of chronic periodontitis
A split mouth, double-blinded, randomized controlled clinical trial was conducted on 20 subjects diagnosed with chronic periodontitis. Quadrants of each subject were randomly assigned to four groups and treated accordingly: Group A, scaling and root planing (SRP): Group B, topical ozonated olive oil (OZO) as an adjunct to scaling and root planing: Group C, topical ozonated olive oil as a monotherapy and: Group D, topical chlorhexidine gel as a monotherapy. The quadrants were analyzed clinically by plaque index, gingival index, sulcus bleeding index, probing pocket depth, and clinical attachment level at baseline, 2, 4, 6 and 8 weeks of time intervals. The subjects were also analyzed for perceived pain, discomfort or tooth hypersensitivity (quadrant wise) on a Visual Analogue Scale (VAS). Additionally, subgingival plaque samples were collected from the two predetermined sites of each quadrant at baseline, 4 and 8 weeks for the analysis of total bacterial counts (TBCs) and the detection of frequency of eight putative periodontopathogens by polymerase chain reaction (PCR) method.
The adjunctive use of the OZO with SRP resulted in a significant improvement (P<0.001) of clinical parameters as well as microbiological parameters over the time and in comparison to the control groups. The OZO as monotherapy also showed a significant improvement (P<0.001) in clinical parameters as well as microbiological parameters over the time without any documented side effects. However, there was a significant increase (P<0.05) in dentinal hypersensitivity following OZO as an adjunct to scaling and root planing therapy.
The OZO, as an adjunctive therapy as well as a mono-therapy is efficient in improving periodontal conditions.
本文旨在评估臭氧橄榄油作为单一疗法以及龈下刮治和根面平整辅助疗法治疗慢性牙周炎的疗效。
对20名诊断为慢性牙周炎的受试者进行了一项口内分组、双盲、随机对照临床试验。将每位受试者的象限随机分为四组并进行相应治疗：A组，龈下刮治和根面平整（SRP）；B组，局部应用臭氧橄榄油（OZO）作为龈下刮治和根面平整的辅助治疗；C组，局部应用臭氧橄榄油作为单一疗法；D组，局部应用氯己定凝胶作为单一疗法。在基线、2周、4周、6周和8周的时间间隔，通过菌斑指数、牙龈指数、龈沟出血指数、探诊深度和临床附着水平对各象限进行临床分析。还采用视觉模拟量表（VAS）对受试者的疼痛、不适或牙齿过敏情况（按象限）进行分析。此外，在基线、4周和8周时从每个象限的两个预定部位采集龈下菌斑样本，用于分析总细菌计数（TBC），并通过聚合酶链反应（PCR）方法检测8种假定牙周病原体的频率。
与对照组相比，OZO联合SRP在一段时间内临床参数和微生物学参数均有显著改善（P<0.001）。OZO作为单一疗法在一段时间内临床参数和微生物学参数也有显著改善（P<0.001），且无任何记录在案的副作用。然而，OZO作为龈下刮治和根面平整治疗的辅助疗法后，牙本质过敏有显著增加（P<0.05）。
OZO作为辅助疗法和单一疗法在改善牙周状况方面均有效。
