van den Berg E, Oosterhuis J W, de Jong B, Buist J, Vos A, Dam A, Vermeij B
Department of Pathology, State University of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1990 Feb;44(2):217-22. doi: 10.1016/0165-4608(90)90050-k.
We present the results of a cytogenetic study of three cases of follicular adenoma of the thyroid. All three cases had a numerical strongly abnormal karyotype with most abnormalities (eg, +4 or +5, +7, +9, +12, +16) in common, possibly indicating that this cluster of abnormalities might be specific for follicular adenomas. For benign tumors, the three cases showed a remarkably abnormal karyotype. These cases are another example of benign tumors with chromosomal abnormalities that might be specific for follicular adenomas.
我们展示了三例甲状腺滤泡性腺瘤的细胞遗传学研究结果。所有三例均具有数量上明显异常的核型，大多数异常（例如，+4或+5、+7、+9、+12、+16）相同，这可能表明这一异常簇可能是滤泡性腺瘤所特有的。对于良性肿瘤而言，这三例显示出明显异常的核型。这些病例是具有可能为滤泡性腺瘤所特有的染色体异常的良性肿瘤的又一实例。
