转移性卵巢卵黄囊瘤的核型分析及DNA流式细胞术

Karyotyping and DNA flow cytometry of metastatic ovarian yolk sac tumor.

作者信息

Vos A, Oosterhuis J W, de Jong B, Castedo S M, Hollema H, Buist J, Aalders J G

机构信息

Department of Medical Genetics, State University of Groningen, The Netherlands.

出版信息

Cancer Genet Cytogenet. 1990 Feb;44(2):223-8. doi: 10.1016/0165-4608(90)90051-b.

DOI:10.1016/0165-4608(90)90051-b

PMID:2297683

Abstract

We karyotyped a metastasis composed of pure yolk sac tumor derived from a primary ovarian germ cell tumor with two components: a dermoid cyst [DNA index (DI) 1.0] and a pure yolk sac tumor (DI 1.88). The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). The absence of this marker in a metastasis from a tumor with a dermoid cyst component might be indicative for a pathogenesis of the yolk sac tumor similar to that of a dermoid cyst and different from that of dysgerminoma.

摘要

我们对一个转移灶进行了核型分析，该转移灶由源自原发性卵巢生殖细胞肿瘤的纯卵黄囊瘤组成，原发性肿瘤包含两个成分：一个皮样囊肿[DNA指数（DI）为1.0]和一个纯卵黄囊瘤（DI为1.88）。转移性卵黄囊瘤具有超三倍体核型，DI为1.78，并且缺乏生殖细胞肿瘤标志物i(12p)。在具有皮样囊肿成分的肿瘤转移灶中缺乏该标志物，可能表明卵黄囊瘤的发病机制与皮样囊肿相似，与无性细胞瘤不同。