Division of Biological Science, College of Science, Sookmyung Women's University, Seoul 140-742, Korea.
Nutr Res Pract. 2012 Aug;6(4):301-7. doi: 10.4162/nrp.2012.6.4.301. Epub 2012 Aug 31.
Radiation used in cancer treatment may cause side effects such as inflammation. Quercetin is a polyphenol that reduces inflammation. This study evaluated the recovery efficacy of quercetin on impaired immune function in irradiation-induced inflammatory mice. Quercetin administered at two concentrations of 10 and 40 mg/kg body weight was initiated 2 weeks before irradiation and was continued 30 days after irradiation. The animals exposed/not exposed to radiation were sacrificed on radiation days 10 and 30. Splenocyte proliferation, which was diminished after irradiation, was enhanced significantly by quercetin supplementation after 30 days of irradiation. Cytokine secretion increased in the radiation group compared to that in the non-radiation control group. After 30 days of radiation, interleukin (IL)-1β and IL-6 secretion decreased significantly in the radiation-quercetin groups. When quercetin was administered for 44 days, it showed a possible protective effect against irradiation-induced inflammation in mice. Quercetin could be beneficial in the recovery of irradiation-induced increases in cytokine secretion.
癌症治疗中使用的辐射可能会引起炎症等副作用。槲皮素是一种多酚，可减轻炎症。本研究评估了槲皮素对辐射诱导的炎症小鼠免疫功能受损的恢复效果。在辐射前 2 周开始给予两种浓度（10 和 40 mg/kg 体重）的槲皮素，并在辐射后继续给予 30 天。暴露/未暴露于辐射的动物在辐射第 10 天和第 30 天被处死。辐射后脾细胞增殖减少，经槲皮素补充后 30 天后显著增强。与非辐射对照组相比，辐射组细胞因子分泌增加。辐射后 30 天，辐射-槲皮素组白细胞介素（IL）-1β和 IL-6 分泌明显下降。当给予槲皮素 44 天时，它对小鼠辐射诱导的炎症表现出可能的保护作用。槲皮素可能有助于恢复辐射诱导的细胞因子分泌增加。
