Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
Sci China Life Sci. 2023 Jul;66(7):1518-1534. doi: 10.1007/s11427-022-2246-4. Epub 2022 Dec 28.
Intensive livestock and poultry farming in China largely relied on the use of in-feed antibiotics until July 2020. The consequences of antibiotic overuse in animal feed include accumulation in animal products and the development of bacterial antibiotic resistance, both of which threaten food safety and human health. China has now completely banned the circulation of commercial feed containing growth-promoting drug additives (except Chinese herbal medicine). Therefore, alternatives to in-feed antibiotics in animal production are greatly needed. Natural phenolic compounds (NPCs) exist widely in plants and are non-toxic, non-polluting, highly reproducible, and leave little residue. Many natural flavonoids, phenolic acids, lignans, and stilbenes have polyphenol chemical structures and exhibit great potential as alternatives to antibiotics. In this review we delineate the characteristics of plant-derived NPCs and summarize their current applications as alternatives to in-feed antibiotics, aiming to provide new strategies for antibiotic-free feeding and promote the development of more sustainable animal husbandry practices.
中国集约化的畜牧业和家禽养殖业在很大程度上依赖于饲料中的抗生素，直到 2020 年 7 月才停止使用。在动物饲料中过度使用抗生素的后果包括在动物产品中的积累和细菌对抗生素的耐药性的发展，这两者都威胁到食品安全和人类健康。中国现在已经完全禁止含有促生长药物添加剂的商业饲料（中草药除外）的流通。因此，动物生产中饲料用抗生素的替代品需求量非常大。天然酚类化合物（NPCs）广泛存在于植物中，具有无毒、无污染、高重现性和低残留等特点。许多天然类黄酮、酚酸、木脂素和芪类化合物具有多酚化学结构，作为抗生素的替代品具有巨大的潜力。在这篇综述中，我们描述了植物来源的 NPCs 的特性，并总结了它们作为饲料用抗生素替代品的应用现状，旨在为无抗生素饲养提供新的策略，并促进更可持续的畜牧业实践的发展。
