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来自[具体来源未给出]的多甲氧基黄酮苏达奇亭可增强BALB/c小鼠的抗原特异性细胞免疫和体液免疫反应。

Sudachitin, polymethoxyflavone from , enhances antigen-specific cellular and humoral immune responses in BALB/c mice.

作者信息

Mitani Mami, Minatogawa Yuki, Nakamoto Akiko, Nakamoto Mariko, Shuto Emi, Nii Yoshitaka, Sakai Tohru

机构信息

Department of Public Health and Applied Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

Food and Biotechnology Division, Tokushima Prefectural Industrial Technology Center, 11-2 Saika-cho, Tokushima 770-8021, Japan.

出版信息

J Clin Biochem Nutr. 2019 Mar;64(2):158-163. doi: 10.3164/jcbn.18-70. Epub 2018 Dec 5.

DOI:10.3164/jcbn.18-70
PMID:30936628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6436041/
Abstract

Scdachitin is a polymethoxyflavone (5,7,4'-trihydroxy-6,8,3-trimethoxyflavone) that is found in the peel of . We examined the effect of sudachitin on immune response in ovalbumin-immunized BALB/c mice. Treatment with sudachitin increased ovalbumin-specific IL-4 and IL-10 productions. In addition, mice that received sudachitin showed higher levels of ovalbumin-specific IgE, IgG1 and IgG l production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl Ficoll was not different in the control and sudachitin groups, suggesting that sudachitin does not directly stimulate antibody production. An study showed that treatment of sudachitin enhanced the ability of antigen presentation in bone marrow-derived dendritic cells. Furthermore, CD11c cells that had been treated with sudachitin showed increased expression of co-stimulatory molecules. The results indicate that sudachitin regulates immune function both and .

摘要

紫苏亭是一种多甲氧基黄酮（5,7,4'-三羟基-6,8,3-三甲氧基黄酮），存在于[具体水果名称缺失]的果皮中。我们研究了紫苏亭对卵清蛋白免疫的BALB/c小鼠免疫反应的影响。用紫苏亭处理可增加卵清蛋白特异性IL-4和IL-10的产生。此外，接受紫苏亭处理的小鼠比对照小鼠表现出更高水平的卵清蛋白特异性IgE、IgG1和IgG2a产生。对照和紫苏亭组对胸腺非依赖性抗原2,4,6-三硝基苯基菲可的抗体反应没有差异，这表明紫苏亭不会直接刺激抗体产生。一项研究表明，紫苏亭处理增强了骨髓来源树突状细胞的抗原呈递能力。此外，用紫苏亭处理的CD11c细胞显示共刺激分子的表达增加。结果表明，紫苏亭在[两个方面缺失]调节免疫功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/50cd295364f8/jcbn18-70f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/6947018a6ce2/jcbn18-70f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/0a104574cb8b/jcbn18-70f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/7e7263d94655/jcbn18-70f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/50cd295364f8/jcbn18-70f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/6947018a6ce2/jcbn18-70f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/0a104574cb8b/jcbn18-70f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/7e7263d94655/jcbn18-70f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c707/6436041/50cd295364f8/jcbn18-70f04.jpg

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