狒狒、黑猩猩和人类对Toll样受体2（TLR2）和Toll样受体4（TLR4）激动剂的先天性免疫反应存在差异。
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.
作者信息
Brinkworth J F, Pechenkina E A, Silver J, Goyert S M
机构信息
Department of Anthropology, Graduate Center, City University of New York, New York, NY, USA.
出版信息
J Med Primatol. 2012 Dec;41(6):388-93. doi: 10.1111/jmp.12002. Epub 2012 Sep 17.
Abstract
BACKGROUND
African catarrhine primates differ in bacterial disease susceptibility.
METHODS
Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR.
RESULTS
Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent.
CONCLUSIONS
These primates tend to generate species rather than agonist-specific responses to bacterial agonists.
摘要
背景
非洲狭鼻猿灵长类动物对细菌性疾病的易感性存在差异。
方法
用人、黑猩猩和狒狒的血液进行Toll样受体（TLR）检测的细菌激动剂刺激，并通过实时聚合酶链反应（PCR）评估细胞因子/趋化因子的诱导情况。
结果
人类和黑猩猩的细胞因子/趋化因子反应相似，而狒狒的细胞因子/趋化因子诱导情况不同。一般来说，反应与激动剂无关。
结论
这些灵长类动物对细菌激动剂倾向于产生物种特异性而非激动剂特异性反应。
相似文献
1
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.狒狒、黑猩猩和人类对Toll样受体2（TLR2）和Toll样受体4（TLR4）激动剂的先天性免疫反应存在差异。
J Med Primatol. 2012 Dec;41(6):388-93. doi: 10.1111/jmp.12002. Epub 2012 Sep 17.
2
Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung.早产狒狒肺中Toll样受体-2和-4的发育表达
Dev Comp Immunol. 2008;32(9):1088-98. doi: 10.1016/j.dci.2008.02.005. Epub 2008 Mar 18.
3
Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products.Toll样受体TLR2和TLR4启动肾小管上皮细胞对细菌产物的固有免疫反应。
Clin Exp Immunol. 2006 Aug;145(2):346-56. doi: 10.1111/j.1365-2249.2006.03116.x.
4
Toll-like receptor responses are suppressed in trauma ICU patients.创伤重症监护病房患者的Toll样受体反应受到抑制。
J Surg Res. 2016 Nov;206(1):139-145. doi: 10.1016/j.jss.2016.06.056. Epub 2016 Jun 25.
5
Level of Toll-like receptor agonist exposure differentially determines chemokine production in humans.Toll样受体激动剂的暴露水平差异决定了人类趋化因子的产生。
Can J Physiol Pharmacol. 2007 Jul;85(7):739-46. doi: 10.1139/Y07-064.
6
Intestinal parasites of baboons (Papio cynocephalus anubis) and chimpanzees (Pan troglodytes) in Gombe National Park.贡贝国家公园中狒狒（东非狒狒）和黑猩猩（黑猩猩）的肠道寄生虫
J Zoo Wildl Med. 2000 Jun;31(2):176-8. doi: 10.1638/1042-7260(2000)031[0176:IPOBPC]2.0.CO;2.
7
[Changes and clinical significance of Toll-like receptor 2 and 4 expression in neonatal infections].[新生儿感染中Toll样受体2和4表达的变化及临床意义]
Zhonghua Er Ke Za Zhi. 2007 Feb;45(2):130-3.
8
Synergism of toll-like receptor 2 (TLR2), TLR4, and TLR6 ligation on the production of tumor necrosis factor (TNF)-alpha in a spontaneous arthritis animal model of interleukin (IL)-1 receptor antagonist-deficient mice.在白细胞介素（IL）-1受体拮抗剂缺陷小鼠的自发性关节炎动物模型中，Toll样受体2（TLR2）、TLR4和TLR6连接对肿瘤坏死因子（TNF）-α产生的协同作用。
Immunol Lett. 2009 Apr 27;123(2):138-43. doi: 10.1016/j.imlet.2009.03.004. Epub 2009 Mar 21.
9
Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.灵长类动物先天免疫对细菌和病毒病原体的反应揭示了强度和特异性之间的进化权衡。
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13). doi: 10.1073/pnas.2015855118.
引用本文的文献
1
A review of gut failure as a cause and consequence of critical illness.作为危重病病因及后果的肠衰竭综述。
Crit Care. 2025 Feb 26;29(1):91. doi: 10.1186/s13054-025-05309-7.
2
Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.灵长类动物先天免疫对细菌和病毒病原体的反应揭示了强度和特异性之间的进化权衡。
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13). doi: 10.1073/pnas.2015855118.
3
TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins.TLR4 信号转导与血红素结合血蛋白的作用。
Front Immunol. 2020 Aug 27;11:1964. doi: 10.3389/fimmu.2020.01964. eCollection 2020.
4
Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.人类进化过程中CMAH的缺失使单核细胞-巨噬细胞谱系倾向于更具炎症性和吞噬性的状态。
J Immunol. 2017 Mar 15;198(6):2366-2373. doi: 10.4049/jimmunol.1601471. Epub 2017 Feb 1.
5
Reservoir host immune responses to emerging zoonotic viruses.储存宿主对新出现的人畜共患病毒的免疫反应。
Cell. 2015 Jan 15;160(1-2):20-35. doi: 10.1016/j.cell.2014.12.003. Epub 2014 Dec 18.
6
Immunological and technical considerations in application of alginate-based microencapsulation systems.海藻酸盐基微囊化系统应用中的免疫学和技术考虑因素。
Front Bioeng Biotechnol. 2014 Aug 6;2:26. doi: 10.3389/fbioe.2014.00026. eCollection 2014.
7
A comparative review of toll-like receptor 4 expression and functionality in different animal species.不同动物物种中Toll样受体4表达与功能的比较综述
Front Immunol. 2014 Jul 10;5:316. doi: 10.3389/fimmu.2014.00316. eCollection 2014.
8
Discordant biological and toxicological species responses to TLR3 activation.TLR3 激活导致的生物和毒理学物种反应不一致。
Am J Pathol. 2014 Apr;184(4):1062-1072. doi: 10.1016/j.ajpath.2013.12.006. Epub 2014 Jan 30.
9
Thyroid autoantibodies are rare in nonhuman great apes and hypothyroidism cannot be attributed to thyroid autoimmunity.甲状腺自身抗体在非人类大型猿类中罕见，而甲状腺功能减退症不能归因于甲状腺自身免疫。
Endocrinology. 2013 Dec;154(12):4896-907. doi: 10.1210/en.2013-1717. Epub 2013 Oct 3.
本文引用的文献
1
Mycobacterium tuberculosis infection in a closed colony of rhesus macaques (Macaca mulatta).恒河猴封闭群体中的结核分枝杆菌感染
J Am Assoc Lab Anim Sci. 2011 Jan;50(1):105-8.
2
Functional comparison of innate immune signaling pathways in primates.灵长类动物固有免疫信号通路的功能比较。
PLoS Genet. 2010 Dec 16;6(12):e1001249. doi: 10.1371/journal.pgen.1001249.
3
Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.人与黑猩猩淋巴细胞的相对过度反应：对与免疫激活相关的人类疾病的影响。
J Immunol. 2010 Apr 15;184(8):4185-95. doi: 10.4049/jimmunol.0903420. Epub 2010 Mar 15.
4
Evolutionary and biomedical insights from the rhesus macaque genome.恒河猴基因组的进化与生物医学见解。
Science. 2007 Apr 13;316(5822):222-34. doi: 10.1126/science.1139247.
5
6
Leveraging human genomic information to identify nonhuman primate sequences for expression array development.利用人类基因组信息鉴定用于表达阵列开发的非人灵长类序列。
BMC Genomics. 2005 Nov 15;6:160. doi: 10.1186/1471-2164-6-160.
7
Initial sequence of the chimpanzee genome and comparison with the human genome.黑猩猩基因组的初始序列及其与人类基因组的比较。
Nature. 2005 Sep 1;437(7055):69-87. doi: 10.1038/nature04072.
8
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid.人类与黑猩猩在疟疾易感性方面差异的演变：与人类N-羟乙酰神经氨酸基因缺失的关系
Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12819-24. doi: 10.1073/pnas.0503819102. Epub 2005 Aug 26.
9
Insights into host responses against pathogens from transcriptional profiling.通过转录谱分析洞察宿主对病原体的反应。
Nat Rev Microbiol. 2005 Apr;3(4):281-94. doi: 10.1038/nrmicro1126.
10
Lipopolysaccharide dose response in baboons.狒狒中脂多糖的剂量反应
Shock. 2003 Nov;20(5):431-6. doi: 10.1097/01.shk.0000090843.66556.74.
Zotero 插件