Hughes J H, Mitchell M, Hamparian V V
Arch Virol. 1979;61(4):313-9. doi: 10.1007/BF01315018.
The kinetics of ultraviolet inactivation for two human rhinoviruses and poliovirus were compared. No major differences in the rates of ultraviolet inactivation were detectable. All viral preparations inactivated by ultraviolet irradiation induced neutralizing antibody in guinea pigs. In contrast, when guinea pigs were immunized with a heat inactivated rhinovirus preparation, little or no neutralizing antibody was elicited. Immune electron microscopy of the heated rhinovirus preparations revealed the presence of particles resembling empty capsids. These results suggest that rhinoviruses and enteroviruses are affected in a similar manner when subjected to ultraviolet or heat inactivation.
比较了两种人鼻病毒和脊髓灰质炎病毒的紫外线灭活动力学。未检测到紫外线灭活速率的重大差异。所有经紫外线照射灭活的病毒制剂在豚鼠中均诱导产生中和抗体。相比之下，当用热灭活的鼻病毒制剂免疫豚鼠时，几乎没有或没有引发中和抗体。对热灭活的鼻病毒制剂进行免疫电子显微镜检查发现存在类似空衣壳的颗粒。这些结果表明，鼻病毒和肠道病毒在受到紫外线或热灭活时受到的影响方式相似。
