Sharifi Mohammad Sharif, Hazell Stuart Loyd
University of New South Wales, Sydney, Australia.
Glob J Health Sci. 2011 Dec 29;4(1):217-28. doi: 10.5539/gjhs.v4n1p217.
The chemical entities of Mastic, Kurdica, Mutica and Cabolica gums from genus Pistacia have been isolated and characterised by GC-Mass Spectrometry, High Performance Liquid Chromatography and Column Chromatography. These chemical entities were screened for anti-microbial activities against nine strains of Helicobacter pylori and some other Gram-negative and Gram-positive bacteria. The most bioactive components were structurally analysed. These components mimic steroid compounds, in particular, the known antibiotic Fusidic acid. Some of these chemical entities have produced promising data that could lead to the development of a novel class of antimicrobial agents that may have application in the treatment of infectious disease. Kill kinetics have been also performed, and the produced data were evaluated by Generalized Multiplicative Analysis Of Variance (GEMANOVA) for the bactericidal and bacteriostatic activities which can be clinically significant. The isolated components were all bactericidal.
黄连木属乳香、库尔德乳香、无刺乳香和卡波乳香的化学实体已通过气相色谱 - 质谱联用、高效液相色谱和柱色谱进行分离和表征。对这些化学实体针对九株幽门螺杆菌以及其他一些革兰氏阴性和革兰氏阳性细菌进行了抗菌活性筛选。对生物活性最强的成分进行了结构分析。这些成分模拟类固醇化合物，特别是已知的抗生素夫西地酸。其中一些化学实体已产生了有前景的数据，这可能会导致开发一类新型抗菌剂，可应用于传染病治疗。还进行了杀灭动力学研究，并通过广义乘法方差分析（GEMANOVA）对杀菌和抑菌活性产生的数据进行评估，这些数据可能具有临床意义。分离出的成分均具有杀菌作用。
