黄连木属天然聚合物的生物活性：其抗菌作用的验证模型。

Bio-activity of natural polymers from the genus Pistacia: a validated model for their antimicrobial action.

作者信息

Sharifi Mohammad Sharif, Ebrahimi Diako, Hibbert David Brynn, Hook James, Hazell Stuart Loyd

机构信息

University of Sydney, Sydney, Australia.

出版信息

Glob J Health Sci. 2011 Dec 29;4(1):149-61. doi: 10.5539/gjhs.v4n1p149.

DOI:10.5539/gjhs.v4n1p149

PMID:22980106

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4777025/

Abstract

The polymers from mastic gum of Pistacia lentiscose and subspecies of Pistacia atlantica, (sp. kurdica, mutica and cabolica) have been isolated and characterised by gel permeation chromatography (GPC) and 13C NMR spectroscopy as cis-1,4-poly-?-myrcenes. They were screened against Helicobacter pylori and other Gram-negative and Gram-positive bacteria to evaluate their antimicrobial action. In order to further test their hypothesised mode of action, two polymer types were synthesized: one from myrcene, and four from polyvinyl alcohols of different molecular weights, derivatised with p-hydroxybenzoate. The anti-microbial activity of these polymers, evaluated through their 'kill' kinetics, was found to be related to their functional groups, their molecular weight and their solubility.

摘要

从乳香黄连木和大西洋黄连木亚种（库尔德亚种、穆蒂卡亚种和卡博利卡亚种）的乳香脂中分离出聚合物，并通过凝胶渗透色谱法（GPC）和13C核磁共振光谱对其进行表征，确定为顺式-1,4-聚-β-月桂烯。对它们针对幽门螺杆菌以及其他革兰氏阴性菌和革兰氏阳性菌进行了筛选，以评估其抗菌作用。为了进一步测试其假定的作用模式，合成了两种类型的聚合物：一种由月桂烯合成，另外四种由不同分子量的聚乙烯醇与对羟基苯甲酸衍生化合成。通过“杀灭”动力学评估这些聚合物的抗菌活性，发现其与官能团、分子量和溶解度有关。