Oda H, Mori R, Miyazono J, Iwasaka T
Arch Virol. 1979;62(3):175-87. doi: 10.1007/BF01317550.
Treatment of Vero cells infected with herpes simplex virus type 2 with the proper concentrations of hydroxyurea (HU) reduced the production of infectious virus and markedly increased the accumulation of tubular structures in the nuclei when the drug was added within 6 hours after infection. Similar accumulation of tubular structures in the infected nuclei was also observed when infected cells were treated with phosphonoacetic acid at proper concentrations. The release of HU-treated, herpes simplex virus type 2-infected cells from the drug-induced blocking of synthesis of infectious virus resulted in the marked decrease of tubular structures coincidentally with the beginning of production of infectious virus. The data suggest the possibility that the disappearance of tubular structures may be related to the active production of infectious virus.
用适当浓度的羟基脲（HU）处理感染了2型单纯疱疹病毒的Vero细胞，当在感染后6小时内加入该药物时，可减少感染性病毒的产生，并显著增加细胞核中管状结构的积累。当用适当浓度的膦甲酸处理感染细胞时，也观察到感染细胞核中类似的管状结构积累。从药物诱导的感染性病毒合成阻断中释放经HU处理的感染了2型单纯疱疹病毒的细胞，会导致管状结构显著减少，同时感染性病毒开始产生。数据表明管状结构的消失可能与感染性病毒的活跃产生有关。
