Diosi P, Georgescu L, Neniu C
Virologie. 1982 Jul-Sep;33(3):199-201.
Thin-section electron microscopy of Herpesvirus hominis type 1 (HV-1)-infected HEp-2 cells exposed to 100 micrograms/ml phosphonoacetic acid (PAA) revealed not only a spatial restriction of virus multiplication to a few spheroid bodies in the nucleus, but also a delay in viral development, resulting in the formation of unusual HV-1 particle rosettes around the spheroid bodies. HV-1-infected cells were lacking, however, the small tubular structures known to accumulate at increased rates in the presence of PAA, in HV-2-infected cells.
用100微克/毫升磷甲酸（PAA）处理1型人疱疹病毒（HV-1）感染的人喉表皮样癌细胞（HEp-2细胞）后进行超薄切片电子显微镜检查，结果显示，病毒增殖不仅在细胞核内的少数球状体中存在空间限制，而且病毒发育延迟，导致在球状体周围形成异常的HV-1颗粒玫瑰花结。然而，HV-1感染的细胞缺乏在PAA存在下已知会以更高速率积累的小管状结构，而在HV-2感染的细胞中则有这种结构。
