胎球蛋白-A 触发游离肿瘤细胞分泌一组新型外泌体，这些外泌体介导游离肿瘤细胞的黏附和铺展。
Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading.
机构信息
Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, United States.
出版信息
FEBS Lett. 2012 Sep 21;586(19):3458-63. doi: 10.1016/j.febslet.2012.07.071. Epub 2012 Aug 8.
Abstract
Our goal in this study was to define the mechanisms by which fetuin-A mediates the adhesion of tumor cells. The data show that in the absence of fetuin-A, detached tumor cells secrete exosomes that contain most of the known exosomal associated proteins but lack the capacity to mediate cellular adhesion. In the presence of fetuin-A, the cells secrete exosomes, which contain, in addition to the other exosomal proteins, fetuin-A, plasminogen and histones. These exosomes mediate adhesion and cell spreading. Plasminogen is a participant in this novel adhesion mechanism. The data suggest that these exosomes play a role in tumor progression.
摘要
我们这项研究的目的是确定胎球蛋白 A 介导肿瘤细胞黏附的机制。数据表明，在没有胎球蛋白 A 的情况下，分离的肿瘤细胞分泌含有大多数已知的外泌体相关蛋白的外泌体，但缺乏介导细胞黏附的能力。在胎球蛋白 A 的存在下，细胞分泌外泌体，除了其他外泌体蛋白外，还含有胎球蛋白 A、纤溶酶原和组蛋白。这些外泌体介导黏附和细胞铺展。纤溶酶原是这种新的黏附机制的参与者。这些数据表明这些外泌体在肿瘤进展中发挥作用。
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