Department of Zoology, University of Delhi, Delhi, 110007, India.
Department of Zoology, Deen Dayal Upadhyaya College, University of Delhi, Delhi, 110078, India.
Mol Cell Biochem. 2022 Feb;477(2):507-524. doi: 10.1007/s11010-021-04300-4. Epub 2021 Nov 18.
Histones are classically known to organize the eukaryotic DNA into chromatin. They are one of the key players in regulating transcriptionally permissive and non-permissive states of the chromatin. Nevertheless, their context-dependent appearance within the cytoplasm and systemic circulation has also been observed. The past decade has also witnessed few scientific communications on the existence of vesicle-associated histones. Diverse groups have attempted to determine the significance of these extra-nuclear histones so far, with many of those studies still underway. Of note amongst these are interactions of extra-nuclear or free histones with cellular membranes, mediated by mutual cationic and anionic natures, respectively. It is here aimed to consolidate the mechanism of formation of extra-nuclear histones; implications of histone-induced membrane destabilization and explore the mechanisms of their association/release with extracellular vesicles, along with the functional aspects of these extra-nuclear histones in cell and systemic physiology.
组蛋白经典地将真核生物 DNA 组织成染色质。它们是调节染色质转录允许和不允许状态的关键因素之一。然而，它们在细胞质和全身循环中的上下文相关出现也已经被观察到。过去十年也见证了一些关于囊泡相关组蛋白存在的科学交流。到目前为止，不同的研究小组已经尝试确定这些核外组蛋白的意义，其中许多研究仍在进行中。值得注意的是，这些研究包括核外或游离组蛋白与细胞膜之间的相互作用，分别由相互的阳离子和阴离子性质介导。本研究旨在整合核外组蛋白形成的机制；组蛋白诱导的膜不稳定的影响，并探讨它们与细胞外囊泡结合/释放的机制，以及这些核外组蛋白在细胞和全身生理学中的功能方面。
