Physical Therapy Program, Department of Kinesiology, University of Connecticut, United States.
Infant Behav Dev. 2012 Dec;35(4):838-46. doi: 10.1016/j.infbeh.2012.07.019. Epub 2012 Sep 13.
Motor delays have been reported in retrospective studies of young infants who later develop Autism Spectrum Disorders (ASDs).
In this study, we prospectively compared the gross motor development of a cohort at risk for ASDs; infant siblings of children with ASDs (AU sibs) to low risk typically developing (LR) infants.
24 AU sibs and 24 LR infants were observed at 3 and 6 months using a standardized motor measure, the Alberta Infant Motor Scale (AIMS). In addition, as part of a larger study, the AU sibs also received a follow-up assessment to determine motor and communication performance at 18 months using the Mullen Scales of Early Learning.
Significantly more AU sibs showed motor delays at 3 and 6 months than LR infants. The majority of the AU sibs showed both early motor delays and later communication delays.
Small sample size and limited follow-up.
Early motor delays are more common in AU sibs than LR infants. Communication delays later emerged in 67-73% of the AU sibs who had presented with early motor delays. Overall, early motor delays may be predictive of future communication delays in children at risk for autism.
在对后来发展出自闭症谱系障碍（ASD）的幼儿的回顾性研究中，报告了运动发育迟缓。
在这项研究中，我们前瞻性地比较了自闭症谱系障碍高风险队列的婴儿的粗大运动发育情况；自闭症儿童的婴儿兄弟姐妹（AU 兄弟姐妹）与低风险正常发育（LR）婴儿。
使用标准化运动评估工具，即阿尔伯塔婴儿运动量表（AIMS），对 24 名 AU 兄弟姐妹和 24 名 LR 婴儿在 3 个月和 6 个月时进行观察。此外，作为更大研究的一部分，AU 兄弟姐妹还接受了后续评估，以使用 Mullen 早期学习量表确定 18 个月时的运动和沟通表现。
与 LR 婴儿相比，3 个月和 6 个月时出现运动迟缓的 AU 兄弟姐妹明显更多。大多数 AU 兄弟姐妹都表现出早期运动迟缓，随后也出现沟通迟缓。
样本量小，随访有限。
AU 兄弟姐妹比 LR 婴儿更常见早期运动迟缓。在出现早期运动迟缓的 AU 兄弟姐妹中，67-73%后来出现了沟通迟缓。总体而言，早期运动迟缓可能预示着自闭症高风险儿童未来的沟通迟缓。
