拼凑拼图碎片：磷脂- G蛋白偶联受体相互作用的当前原子水平图景
Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.
作者信息
Parrill Abby L, Tigyi Gabor
机构信息
Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA.
出版信息
Biochim Biophys Acta. 2013 Jan;1831(1):2-12. doi: 10.1016/j.bbalip.2012.09.002. Epub 2012 Sep 12.
Abstract
A compelling question of how phospholipids interact with their target receptors has been of interest since the first receptor-mediated effects were reported. The recent report of a crystal structure for the S1P(1) receptor in complex with an antagonist phospholipid provides interesting perspective on the insights that had previously been gained through structure-activity studies of the phospholipids, as well as modeling and mutagenesis studies of the receptors. This review integrates these varied lines of investigation in the context of their various contributions to our current understanding of phospholipid-receptor interactions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
摘要
自首次报道受体介导的效应以来，磷脂如何与其靶受体相互作用这一引人关注的问题一直备受关注。最近关于S1P(1)受体与拮抗剂磷脂复合物晶体结构的报道，为先前通过磷脂构效关系研究以及受体建模和诱变研究获得的见解提供了有趣的视角。本综述在它们对我们目前对磷脂 - 受体相互作用理解的各种贡献的背景下，整合了这些不同的研究方向。本文是名为《溶血磷脂研究进展》特刊的一部分。
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