Conaway Ronald C, Conaway Joan Weliky
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Biochim Biophys Acta. 2013 Jan;1829(1):69-75. doi: 10.1016/j.bbagrm.2012.08.017. Epub 2012 Sep 13.
Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription.
We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation.
Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination.
Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
中介体是一种进化上保守的多亚基RNA聚合酶II（Pol II）共调节复合物。尽管中介体最初被发现对Pol II转录起始的调控起关键作用，但最近的研究揭示了中介体在转录起始后阶段发挥的更广泛作用。
我们简要描述了中介体的结构及其在Pol II转录起始调控中的功能，并总结了近期表明中介体参与Pol II转录延伸各阶段调控的研究发现。
新出现的证据揭示了中介体在Pol II转录几乎所有阶段（包括起始、启动子逃逸、延伸、前体mRNA加工和终止）的新作用。
中介体通过影响mRNA合成的几乎所有阶段，在基因表达调控中发挥核心作用。本文是名为“RNA聚合酶II转录延伸”的特刊的一部分。
