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Direct interaction of RNA polymerase II and mediator required for transcription in vivo.RNA 聚合酶 II 与介导因子的直接相互作用是体内转录所必需的。
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Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae.在酿酒酵母中，介体在调节 Pol II 延伸和核小体位移中的作用。
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7
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Arabidopsis MED18 Interaction With RNA Pol IV and V Subunit NRPD2a in Transcriptional Regulation of Plant Immune Responses.拟南芥MED18与RNA聚合酶IV和V亚基NRPD2a在植物免疫反应转录调控中的相互作用
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本文引用的文献

1
Human mediator subunit MED26 functions as a docking site for transcription elongation factors.人类中介体亚基 MED26 作为转录延伸因子的对接位点发挥作用。
Cell. 2011 Jul 8;146(1):92-104. doi: 10.1016/j.cell.2011.06.005.
2
The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development.拟南芥 Med25 中介体亚基整合环境线索控制植物发育。
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8245-50. doi: 10.1073/pnas.1002981108. Epub 2011 May 2.
3
Structure and VP16 binding of the Mediator Med25 activator interaction domain.中介体 Med25 激活因子相互作用结构域的结构与 VP16 结合。
Nat Struct Mol Biol. 2011 Apr;18(4):404-9. doi: 10.1038/nsmb.1997. Epub 2011 Mar 6.
4
Structure of the VP16 transactivator target in the Mediator.中介体中 VP16 转录激活因子靶标的结构。
Nat Struct Mol Biol. 2011 Apr;18(4):410-5. doi: 10.1038/nsmb.1999. Epub 2011 Mar 6.
5
Function and regulation of the Mediator complex.中介复合物的功能和调节。
Curr Opin Genet Dev. 2011 Apr;21(2):225-30. doi: 10.1016/j.gde.2011.01.013. Epub 2011 Feb 15.
6
Overexpression of LCMR1 is significantly associated with clinical stage in human NSCLC.LCMR1 的过表达与人非小细胞肺癌的临床分期显著相关。
J Exp Clin Cancer Res. 2011 Feb 9;30(1):18. doi: 10.1186/1756-9966-30-18.
7
Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver.Med25 对于 RNA 聚合酶 II 招募到特定启动子是必需的，从而调节人肝脏中的外来物质和脂质代谢。
Mol Cell Biol. 2011 Feb;31(3):466-81. doi: 10.1128/MCB.00847-10. Epub 2010 Dec 6.
8
NMR structure of the human Mediator MED25 ACID domain.人类中介体 MED25 ACID 结构域的 NMR 结构。
J Struct Biol. 2011 Apr;174(1):245-51. doi: 10.1016/j.jsb.2010.10.011. Epub 2010 Oct 23.
9
Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae.转录中介体亚基在调控酿酒酵母多药耐药基因表达中的差异作用。
Mol Biol Cell. 2010 Jul 15;21(14):2469-82. doi: 10.1091/mbc.e09-10-0899. Epub 2010 May 26.
10
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.HIV-1 Tat 组装多功能转录延伸复合物，并与 7SK snRNP 稳定结合。
Mol Cell. 2010 May 14;38(3):439-51. doi: 10.1016/j.molcel.2010.04.012.

中介体复合物的起源和活性。

Origins and activity of the Mediator complex.

机构信息

Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.

出版信息

Semin Cell Dev Biol. 2011 Sep;22(7):729-34. doi: 10.1016/j.semcdb.2011.07.021. Epub 2011 Jul 28.

DOI:10.1016/j.semcdb.2011.07.021
PMID:21821140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3207015/
Abstract

The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.

摘要

中介体是一个大型的多亚基 RNA 聚合酶 II 转录调控因子，最初在酿酒酵母中被鉴定为 Pol II 和一般起始因子对 DNA 结合转录激活因子的反应所必需的因子。自其在酵母中的发现以来，中介体已被证明是 Pol II 转录机制的一个不可或缺的高度进化保守的组成部分，在转录的多个阶段都具有关键作用，从 Pol II 起始复合物组装的调节到 Pol II 延伸的调节。在这里，我们简要概述了中介体的进化起源、其亚基组成以及其在 Pol II 转录中极其多样化的活性。