中介体复合物的起源和活性。
Origins and activity of the Mediator complex.
机构信息
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA.
出版信息
Semin Cell Dev Biol. 2011 Sep;22(7):729-34. doi: 10.1016/j.semcdb.2011.07.021. Epub 2011 Jul 28.
Abstract
The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.
摘要
中介体是一个大型的多亚基 RNA 聚合酶 II 转录调控因子，最初在酿酒酵母中被鉴定为 Pol II 和一般起始因子对 DNA 结合转录激活因子的反应所必需的因子。自其在酵母中的发现以来，中介体已被证明是 Pol II 转录机制的一个不可或缺的高度进化保守的组成部分，在转录的多个阶段都具有关键作用，从 Pol II 起始复合物组装的调节到 Pol II 延伸的调节。在这里，我们简要概述了中介体的进化起源、其亚基组成以及其在 Pol II 转录中极其多样化的活性。
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