Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Ann Behav Med. 2013 Feb;45(1):57-68. doi: 10.1007/s12160-012-9406-1.
Worry about cancer progression and perceived social support can affect cancer survivors' quality of life (QOL).
In 480 early-stage breast cancer survivors, we examined how worry about cancer progression and perceived social support 6 months after definitive surgery were associated with QOL (RAND 36-item Health Survey) at 6-, 12-, and 24-month follow-up.
At 6 months post-surgery, higher worry was associated with worse QOL for five of eight subscales. Lower social support was associated with worse QOL for four subscales. The negative effects of worry and limited social support dissipated for four subscales (worry) and two subscales (social support) by 12-month follow-up and for all subscales by 24-month follow-up. Social support at 6 months moderated the relationship between T2 worry and T4 emotional well-being; post hoc tests did not clarify the nature of the interaction.
Early-stage breast cancer survivors who worry about cancer progression and/or have low social support may experience lower levels of QOL that can take several months to resolve.
对癌症进展的担忧和感知到的社会支持会影响癌症幸存者的生活质量（QOL）。
在 480 名早期乳腺癌幸存者中，我们研究了明确手术后 6 个月时对癌症进展的担忧和感知到的社会支持如何与 6、12 和 24 个月随访时的 QOL（RAND 36 项健康调查）相关。
在手术后 6 个月时，较高的担忧与八个子量表中的五个子量表的 QOL 较差相关。较低的社会支持与四个子量表的 QOL 较差相关。担忧的负面影响（四个子量表）和社会支持的负面影响（两个子量表）在 12 个月随访时消散，所有子量表在 24 个月随访时消散。6 个月时的社会支持调节了 T2 担忧与 T4 情绪健康之间的关系；事后检验未能阐明相互作用的性质。
对癌症进展担忧和/或社会支持较低的早期乳腺癌幸存者可能会经历几个月才能解决的较低 QOL 水平。
