Trinity College Dublin, St Patrick's University Hospital, James Street, Dublin 8, Ireland.
Curr Psychiatry Rep. 2012 Dec;14(6):659-66. doi: 10.1007/s11920-012-0320-9.
Bipolar disorder and alcohol use disorder represent a significant comorbid population, which is significantly worse than either diagnosis alone in presentation, duration, co-morbidity, cost, suicide rate, and poor response to treatment. They share some common characteristics in relation to genetic background, neuroimaging findings, and some biochemical findings. They can be treated with separate care, or ideally some form of integrated care. There are a number of pharmacotherapy trials, and psychotherapy trials that can aid program development. Post-treatment prognosis can be influenced by a number of factors including early abstinence, baseline low anxiety, engagement with an aftercare program and female gender. The future development of novel therapies relies upon increased psychiatric and medical awareness of the co-morbidity, and further research into novel therapies for the comorbid group.
双相情感障碍和酒精使用障碍代表了一个重要的共病群体，其表现、持续时间、合并症、成本、自杀率和治疗反应差等方面均显著差于单一诊断。它们在遗传背景、神经影像学发现和一些生化发现方面具有一些共同特征。它们可以通过单独的护理或理想的某种形式的综合护理来治疗。有许多药物治疗试验和心理治疗试验可以帮助制定方案。治疗后的预后可能受到多种因素的影响，包括早期戒断、基线低焦虑、参与后续护理计划和女性性别。新型治疗方法的未来发展取决于精神科和医学对共病的认识的提高，以及对共病群体的新型治疗方法的进一步研究。
