Nurita Rahma, Faturohman Adit, Santoso Febrina Mustika, Magdalena Bianca, Ilyas Muhana Fawwazy
Medical Doctor Program, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Emergency Department, Ciremai Military Hospital, Cirebon, West Java, Indonesia.
Middle East J Dig Dis. 2025 Jan;17(1):68-75. doi: 10.34172/mejdd.2025.411. Epub 2025 Jan 31.
Gastroesophageal reflux disease (GERD) and bipolar disorder impose substantial global burdens on individuals and healthcare systems. Previous studies suggest a bidirectional association between GERD and bipolar disorder. By searching and reviewing the results of existing studies, this systematic review and meta-analysis aims to review the two-way relationship between GERD and bipolar disorder.
This study adhered to PRISMA Guidelines, including a comprehensive search of PubMed and Scopus for observational longitudinal studies. Quality (risk of bias) assessment employed the Newcastle-Ottawa Scale, and RevMan version 5.3 facilitated meta-analysis.
Five longitudinal studies (161888 patients) revealed a significant bidirectional link between GERD and bipolar disorder. Patients with GERD had a 2.29-fold higher risk of bipolar disorder (OR=2.29 [1.64, 3.21]; <0.001), while individuals with bipolar disorder had a 2.80-fold higher risk of GERD (OR=2.80 [1.36, 5.76]; =0.005). This study also identified independent risk factors, including sex, age under 60 years, and alcohol consumption disorders, influencing the occurrence of bipolar disorder in patients with GERD, as well as there is an influence of the number of psychoactive drugs in the occurrence of GERD in patients with bipolar disorder.
These findings highlight a bidirectional relationship between GERD and bipolar disorder, emphasizing the necessity for integrated care models and personalized treatment plans. The results underscore the importance of considering both gastrointestinal and mental health aspects in managing these interconnected conditions.
胃食管反流病（GERD）和双相情感障碍给个人和医疗保健系统带来了巨大的全球负担。先前的研究表明GERD与双相情感障碍之间存在双向关联。通过搜索和回顾现有研究结果，本系统评价和荟萃分析旨在综述GERD与双相情感障碍之间的双向关系。
本研究遵循PRISMA指南，包括全面检索PubMed和Scopus以查找观察性纵向研究。质量（偏倚风险）评估采用纽卡斯尔-渥太华量表，RevMan 5.3版本辅助进行荟萃分析。
五项纵向研究（161888名患者）揭示了GERD与双相情感障碍之间存在显著的双向联系。GERD患者患双相情感障碍的风险高2.29倍（OR=2.29 [1.64, 3.21]；<0.001），而双相情感障碍患者患GERD的风险高2.80倍（OR=2.80 [1.36, 5.76]；=0.005）。本研究还确定了独立风险因素，包括性别、60岁以下年龄和酒精使用障碍，这些因素影响GERD患者双相情感障碍的发生，以及精神活性药物的数量对双相情感障碍患者GERD发生的影响。
这些发现突出了GERD与双相情感障碍之间的双向关系，强调了综合护理模式和个性化治疗计划的必要性。结果强调了在管理这些相互关联的疾病时考虑胃肠道和心理健康方面的重要性。
