Division of Infectious Diseases, Global Health Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, Ohip 45229, USA.
J Infect Dis. 2012 Dec 1;206(11):1670-3. doi: 10.1093/infdis/jis592. Epub 2012 Sep 14.
We report the immunogenicity of trivalent influenza immunization in 29 pregnant women compared with 22 nonpregnant women. We obtained blood specimens on day 0 prior to 2011-2012 influenza vaccine administration and day 28 after immunization. Hemagglutination inhibition (HAI) geometric mean titers were similar before immunization but were significantly reduced by 40%-50% in pregnant women after immunization for influenza A/California(H1N1) (P = .027) and A/Perth(H3N2) (P = .037). Postimmunization HAI titers were similar between groups for influenza B/Brisbane (P = .390). The geometric mean ratio (fold increase) for influenza A(H1N1) was nonsignificantly reduced in pregnant participants (P = .089). The percentages of participants who seroconverted and achieved seroprotection were similar between groups.
我们报告了 29 名孕妇和 22 名非孕妇接种三价流感疫苗的免疫原性。我们在 2011-2012 年流感疫苗接种前的第 0 天和接种后第 28 天采集了血样。在接种前，血凝抑制（HAI）几何平均滴度相似，但孕妇接种后 A/加利福尼亚（H1N1）（P =.027）和 A/珀斯（H3N2）（P =.037）的滴度分别显著降低了 40%-50%。流感 B/Brisbane 两组之间的 HAI 滴度相似（P =.390）。孕妇参与者中 A（H1N1）的几何平均比值（倍数增加）无显著降低（P =.089）。两组中血清转化率和达到血清保护率的百分比相似。
