Center of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium.
J Infect Dis. 2012 Dec 1;206(11):1790-7. doi: 10.1093/infdis/jis594. Epub 2012 Sep 14.
In this study, we demonstrated that in vitro Candida albicans biofilms grown in the presence of diclofenac showed increased susceptibility to caspofungin. These findings were further confirmed using a catheter-associated biofilm model in rats. C. albicans-inoculated catheters retrieved from rats that were treated with both diclofenac and caspofungin contained significantly fewer biofilm cells and showed no visible biofilms inside the catheter lumens, as documented by scanning electron microscopy, as compared to catheters retrieved from rats receiving only caspofungin or diclofenac. This report indicates that diclofenac could be useful in combination therapy with caspofungin to treat C. albicans biofilm-associated infections.
在这项研究中，我们证明了在体外培养的白色念珠菌生物膜中加入双氯芬酸后，对卡泊芬净的敏感性增加。这些发现使用大鼠导管相关生物膜模型进一步得到证实。与仅接受卡泊芬净或双氯芬酸治疗的大鼠中取出的导管相比，用双氯芬酸和卡泊芬净治疗的大鼠中取出的白色念珠菌接种导管含有明显更少的生物膜细胞，并且在导管内腔中没有可见的生物膜，这通过扫描电子显微镜记录。本报告表明，双氯芬酸与卡泊芬净联合治疗白色念珠菌生物膜相关感染可能是有用的。
