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消除脑膜炎球菌病的前景。

Prospects for eradication of meningococcal disease.

机构信息

Department of Paediatric Intensive Care, St Marys Hospital, Praed Street, London, UK.

出版信息

Arch Dis Child. 2012 Nov;97(11):993-8. doi: 10.1136/archdischild-2012-302036. Epub 2012 Sep 15.

DOI:10.1136/archdischild-2012-302036
PMID:22984187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3512348/
Abstract

Meningococcal meningitis and septicaemia remain a serious global health threat. This review focuses on the epidemiology of meningococcal disease following the recent implementation of effective vaccines and the potential utility of a vaccine against serogroup B meningococcus.

摘要

脑膜炎球菌性脑膜炎和败血症仍然是一个严重的全球健康威胁。本综述重点讨论了最近实施有效疫苗后脑膜炎球菌病的流行病学，以及针对 B 群脑膜炎球菌的疫苗的潜在效用。

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本文引用的文献

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Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: a randomized controlled trial.根据不同免疫计划，与常规婴儿疫苗联合或不联合使用时重组 B 群脑膜炎球菌疫苗的免疫原性和耐受性：一项随机对照试验。
JAMA. 2012 Feb 8;307(6):573-82. doi: 10.1001/jama.2012.85.
2
Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study.在智利健康青少年中，一种包含多种脑膜炎奈瑟菌 B 群（4CMenB）组份的疫苗的免疫原性和耐受性：一项 2b/3 期、随机、观察者盲、安慰剂对照研究。
Lancet. 2012 Feb 18;379(9816):617-24. doi: 10.1016/S0140-6736(11)61713-3. Epub 2012 Jan 18.
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Expert Rev Vaccines. 2011 Sep;10(9):1337-51. doi: 10.1586/erv.11.103.
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Preclinical evidence for the potential of a bivalent fHBP vaccine to prevent Neisseria meningitidis Serogroup C Disease.二价因子H结合蛋白（fHBP）疫苗预防脑膜炎奈瑟菌C群疾病潜力的临床前证据。
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