反向疫苗学：基因组学时代的疫苗开发。
Reverse vaccinology: developing vaccines in the era of genomics.
机构信息
La Jolla Institute for Allergy and Immunology, San Diego, CA 92130, USA.
出版信息
Immunity. 2010 Oct 29;33(4):530-41. doi: 10.1016/j.immuni.2010.09.017.
Abstract
The sequence of microbial genomes made all potential antigens of each pathogen available for vaccine development. This increased by orders of magnitude potential vaccine targets in bacteria, parasites, and large viruses and revealed virtually all their CD4(+) and CD8(+) T cell epitopes. The genomic information was first used for the development of a vaccine against serogroup B meningococcus, and it is now being used for several other bacterial vaccines. In this review, we will first summarize the impact that genome sequencing has had on vaccine development, and then we will analyze how the genomic information can help further our understanding of immunity to infection or vaccination and lead to the design of better vaccines by diving into the world of T cell immunity.
摘要
微生物基因组序列使每个病原体的所有潜在抗原都可用于疫苗开发。这使得细菌、寄生虫和大型病毒的潜在疫苗靶点数量增加了几个数量级，并揭示了它们几乎所有的 CD4(+)和 CD8(+)T 细胞表位。基因组信息最初被用于开发针对 B 群脑膜炎球菌的疫苗，现在正被用于其他几种细菌疫苗。在这篇综述中，我们首先总结了基因组测序对疫苗开发的影响，然后通过深入研究 T 细胞免疫的世界，分析基因组信息如何帮助我们进一步了解感染或接种疫苗的免疫反应，并设计更好的疫苗。
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