Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing, China.
PLoS One. 2012;7(9):e45290. doi: 10.1371/journal.pone.0045290. Epub 2012 Sep 12.
Lysosomal protein transmembrane 4 beta (LAPTM4B) is a novel cancer-related gene which has two alleles designated LAPTM4B1 and LAPTM4B2. In this study we investigated the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who had undergone curative resection for gallbladder carcinoma (GBC).
METHODOLOGY/PRINCIPAL FINDINGS: PCR assay was performed to determine the LAPTM4B genotype in 85 patients. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is a prognostic factor for OS and DFS (both P<0.001).
CONCLUSIONS/SIGNIFICANCE: LAPTM4B allele *2 is a risk factor associated with poor prognosis in patients with resected GBC, and LAPTM4B status may be therefore be useful preoperatively as an adjunct in evaluation of the operability of GBC.
溶酶体蛋白跨膜 4β（LAPTM4B）是一种新型的癌症相关基因，有两个等位基因，分别命名为 LAPTM4B1 和 LAPTM4B2。本研究旨在探讨 LAPTM4B 基因型与行根治性切除术的胆囊癌（GBC）患者预后及临床病理特征的相关性。
方法/主要发现：采用 PCR 法检测 85 例患者的 LAPTM4B 基因型。采用卡方检验评估 LAPTM4B 基因型与临床病理参数的相关性。采用 Kaplan-Meier 法确定患者生存差异。采用 Cox 回归分析进行预后因素的多因素分析。携带 LAPTM4B*2 的患者总生存期（OS）和无病生存期（DFS）均显著缩短（均 P<0.001）。多因素分析显示 LAPTM4B 基因型是 OS 和 DFS 的预后因素（均 P<0.001）。
结论/意义：LAPTM4B 等位基因*2 是 GBC 患者预后不良的危险因素，LAPTM4B 状态可能有助于术前评估 GBC 的可切除性。
