Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Sweden.
BMC Gastroenterol. 2012 Sep 17;12:125. doi: 10.1186/1471-230X-12-125.
A gluten-free diet is the only available treatment for celiac disease. Our aim was to investigate the effect of a gluten-free diet on celiac disease related symptoms, health care consumption, and the risk of developing associated immune-mediated diseases.
A questionnaire was sent to 1,560 randomly selected members of the Swedish Society for Coeliacs, divided into equal-sized age- and sex strata; 1,031 (66%) responded. Self-reported symptoms, health care consumption (measured by health care visits and hospitalization days), and missed working days were reported both for the year prior to diagnosis (normal diet) and the year prior to receiving the questionnaire while undergoing treatment with a gluten-free diet. Associated immune-mediated diseases (diabetes mellitus type 1, rheumatic disease, thyroid disease, vitiligo, alopecia areata and inflammatory bowel disease) were self-reported including the year of diagnosis.
All investigated symptoms except joint pain improved after diagnosis and initiated gluten-free diet. Both health care consumption and missed working days decreased. Associated immune-mediated diseases were diagnosed equally often before and after celiac disease diagnosis.
Initiated treatment with a gluten-free diet improves the situation for celiac disease patients in terms of reduced symptoms and health care consumption. An earlier celiac disease diagnosis is therefore of great importance.
无麸质饮食是治疗乳糜泻的唯一方法。我们的目的是研究无麸质饮食对乳糜泻相关症状、医疗保健消费以及发展相关免疫介导性疾病的风险的影响。
向瑞典乳糜泻协会的 1560 名随机成员发送了一份问卷，分为等大小的年龄和性别层；有 1031 名（66%）做出了回应。报告了诊断前一年（正常饮食）和接受问卷前一年（在无麸质饮食治疗期间）的自我报告症状、医疗保健消费（通过就诊次数和住院天数衡量）和缺勤天数。自身免疫性疾病（1 型糖尿病、风湿性疾病、甲状腺疾病、白癜风、斑秃和炎症性肠病）也包括在诊断年份在内。
除了关节痛之外，所有调查到的症状在诊断和开始无麸质饮食后都有所改善。医疗保健消费和缺勤天数都减少了。在乳糜泻诊断前后，自身免疫性疾病的诊断频率相等。
开始无麸质饮食治疗可改善乳糜泻患者的病情，减少症状和医疗保健消费。因此，早期诊断乳糜泻非常重要。
