一种实用的方法，用于通过 NaSO2CF3 和叔丁基过氧化氢 (TBHP) 衍生的 CF3 自由基实现芳基硼酸的 Cu 介导三氟甲基化反应。
Practical method for the Cu-mediated trifluoromethylation of arylboronic acids with CF3 radicals derived from NaSO2CF3 and tert-butyl hydroperoxide (TBHP).
机构信息
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
出版信息
Org Lett. 2012 Oct 5;14(19):4979-81. doi: 10.1021/ol3022726. Epub 2012 Sep 17.
Abstract
A mild and practical protocol for the copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids using NaSO(2)CF(3) (Langlois' reagent) and TBHP is described. The reaction proceeds at room temperature under ambient conditions, and the products can be readily purified by extraction or column chromatography.
摘要
本文描述了一种温和实用的方法，用于在铜催化下用 NaSO(2)CF(3)（朗格卢瓦试剂）和 TBHP 对芳基和杂芳基硼酸进行三氟甲基化。该反应在室温下，在环境条件下进行，产物可以通过萃取或柱色谱法轻松纯化。
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