Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon-do, Republic of Korea.
Org Lett. 2012 Oct 5;14(19):5002-5. doi: 10.1021/ol302115z. Epub 2012 Sep 17.
Two previously unreported spiro-cyclopentenones, spirobacillenes A (1) and B (2), were isolated from the 24 h broth culture of Lysinibacillus fusiformis KMC003 derived from acidic coal-mine drainage. The structures of 1 and 2 were elucidated by analyses of the NMR, HRFABMS, single-crystal X-ray diffraction crystallography, and circular dichroism (CD) spectral data. Compound 1 possessed moderate inhibitory activity against the production of nitric oxide (NO) and reactive oxygen species (ROS).
从酸性煤矿排水中分离到梭状芽孢杆菌 KMC003 的 24 小时发酵液中，分离得到了两个以前未报道的螺环环戊烯酮，即螺杆菌 A（1）和 B（2）。通过 NMR、HRFABMS、单晶 X 射线衍射结晶学和圆二色性（CD）光谱数据分析，确定了 1 和 2 的结构。化合物 1 对一氧化氮（NO）和活性氧（ROS）的产生具有中等抑制活性。
